Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewKC 12291 hydrochloride
Discontinued Product
3251 has been discontinued.
View all Voltage-gated Sodium (Na<sub>V</sub>) Channels products.
Description: Orally active atypical Na+ channel blocker; cardioprotective
Chemical Name: 3,4-Dimethoxy-N-methyl-N-[3-[(5-phenyl-1,2,4-thiadiazol-3-yl)oxy]propyl]benzeneethanamine hydrochloride
Purity: ≥97% (HPLC)
Biological Activity for KC 12291 hydrochloride
KC 12291 hydrochloride is an orally active atypical voltage-gated sodium channel blocker. Inhibits sustained sodium currents (INaL) and prevents diastolic contracture in isolated atria in vitro (IC50 values are 9.6 and 0.55 - 0.79 μM respectively). Displays anti-ischemic, bradycardic and cardioprotective activity in vivo.
Technical Data for KC 12291 hydrochloride
| M. Wt | 449.99 |
| Formula | C22H27N3O3S.HCl |
| Storage | Desiccate at +4°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 181936-98-1 |
| PubChem ID | 22902387 |
| InChI Key | KIJPRQYBNQKUAU-UHFFFAOYSA-N |
| Smiles | CN(CCCOC2=NSC(C3=CC=CC=C3)=N2)CCC1=CC=C(OC)C(OC)=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for KC 12291 hydrochloride
References for KC 12291 hydrochloride
References are publications that support the biological activity of the product.
Tamareille et al (2002) Anti-ischemic compound KC 12291 prevents diastolic contracture in isolated atria by blockade of voltage-gated sodium channels. J.Cardiovasc.Pharmacol. 40 346 PMID: 12198320
John et al (2004) KC 12291: an atypical sodium channel blocker with myocardial antiischemic properties. Cardiovasc.Drug Rev. 22 17 PMID: 14978516
Letienne et al (2006) Pharmacological characterisation of sodium channels in sinoatrial node pacemaking in the rat heart. Eur.J.Pharmacol. 530 243 PMID: 16368090
Decking et al (1998) Cardioprotective actions of KC 12291. Naunyn-Schmied.Arch.Pharmacol. 358 547
View Related Products by Target
View Related Products by Product Action
Keywords: KC 12291 hydrochloride, KC 12291 hydrochloride supplier, Orally, active, atypical, Na+, blockers, cardioprotective, Sodium, NaV, Channels, voltage-gated, voltage-dependent, KC12291, hydrochloride, Voltage-gated, 3251, Tocris Bioscience
Citations for KC 12291 hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for KC 12291 hydrochloride.
Reviews for KC 12291 hydrochloride
There are currently no reviews for this product. Be the first to review KC 12291 hydrochloride and earn rewards!
Have you used KC 12291 hydrochloride?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image