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Submit ReviewKisspeptin 10 (rat)
Description: Endogenous ligand for kisspeptin receptor
Purity: ≥95% (HPLC)
Biological Activity for Kisspeptin 10 (rat)
Kisspeptin 10 (rat) is an endogenous ligand for the rodent kisspeptin receptor (KISS1, GPR54).
Human Analog also available.
Technical Data for Kisspeptin 10 (rat)
| M. Wt | 1318.45 |
| Formula | C63H83N17O15 |
| Sequence | YNWNSFGLRY-NH2 |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 478507-53-8 |
| PubChem ID | 90488921 |
| InChI Key | HVPGTDOCSYBNFC-INXYWQKQSA-N |
| Smiles | [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Kisspeptin 10 (rat)
| Solubility | Soluble to 2 mg/ml in water |
Product Datasheets for Kisspeptin 10 (rat)
References for Kisspeptin 10 (rat)
References are publications that support the biological activity of the product.
Stafford et al (2002) Identification and characterization of mouse metastasis-suppressor KiSS1 and its G-protein-coupled receptor. Cancer Res. 62 5399 PMID: 12359743
Navarro et al (2004) Developmental and hormonally regulated messenger ribonucleic acid expression of KiSS-1 and its putative receptor, GPR54, in rat hypothalamus and potent luteinizing hormone-releasing activity of KiSS-1 peptide. Endocrinology 145 4565 PMID: 15242985
If you know of a relevant reference for Kisspeptin 10 (rat), please let us know.
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Keywords: Kisspeptin 10 (rat), Kisspeptin 10 (rat) supplier, Endogenous, ligands, KISS1, receptors, hOT7T175/AXOR12/GPR54, Metastin, KISS-derived, Peptide, Kisspeptin10, Kisspeptin, Receptor, 4243, Tocris Bioscience
10 Citations for Kisspeptin 10 (rat)
Citations are publications that use Tocris products. Selected citations for Kisspeptin 10 (rat) include:
Varykina G et al (2019) Insulin-induced hypoglycaemia suppresses pulsatile luteinising hormone secretion and arcuate Kiss1 cell activation in female mice. J Neuroendocrinol 31 e12813 PMID: 31758872
Pamela L et al (2019) Deletion of the Homeodomain Protein Six6 From GnRH Neurons Decreases GnRH Gene Expression, Resulting in Infertility. Endocrinology 160 2151-2164 PMID: 31211355
Tonsfeldt et al (2019) The Contribution of the Circadian Gene Bmal1 to Female Fertility and the Generation of the Preovulatory Luteinizing Hormone Surge. J Endocr Soc 3 716 PMID: 30906911
T John et al (2013) β-Arrestin 2 is a mediator of GnRH-(1-5) signaling in immortalized GnRH neurons. Endocrinology 154 4726-36 PMID: 24140715
Rogéria et al (2022) Kisspeptin treatment improves fetal-placental development and blocks placental oxidative damage caused by maternal hypothyroidism in an experimental rat model. Front Endocrinol (Lausanne) 13 908240 PMID: 35966095
Pamela L et al (2022) Female fertility does not require Bmal1 in suprachiasmatic nucleus neurons expressing arginine vasopressin, vasoactive intestinal peptide, or neuromedin-S. Front Endocrinol (Lausanne) 13 956169 PMID: 35992114
Schoeller et al (2016) Bmal1 Is Required for Normal Reproductive Behaviors in Male Mice. Endocrinology 157 4914 PMID: 27704948
Pineda et al (2016) Amygdala Kisspeptin Neurons: Putative Mediators of Olfactory Control of the Gonadotropic Axis. Neuroendocrinology 104 223 PMID: 27054958
Juneo Freitas et al (2023) Kisspeptin Suppresses Inflammasome-NLRP3 Activation and Pyroptosis Caused by Hypothyroidism at the Maternal-Fetal Interface of Rats. Int J Mol Sci 24 PMID: 37047793
Duong et al (2021) The transcription factors SIX3 and VAX1 are required for suprachiasmatic nucleus circadian output and fertility in female mice. J Neurosci Res 99 2625-2645 PMID: 34212416
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