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Submit ReviewKlotho-derived peptide 1
Description: TGF-β receptor 2 (TβR2) binding peptide; disrupts the TGF-β/TβR2 interaction
Purity: ≥95% (HPLC)
Biological Activity for Klotho-derived peptide 1
Klotho-derived peptide 1 (KP1) is a peptide that binds to TGF-β receptor 2 (TβR2) (Kd = 1.4 μM). It inhibits TGF-β signaling by blocking TGF-β/TβR2 interaction. In mouse models of renal fibrosis, intravenous injection of KP1 results in its specific accumulation in the injured kidneys. It suppresses TGF-β signaling, repressing fibroblast activation and ameliorates kidney fibrosis in vivo.
Technical Data for Klotho-derived peptide 1
| M. Wt | 3228.48 |
| Formula | C149H203N39O43 |
| Sequence | FQGTFPDGFLWAVGSAAYQTEGGWQQHGKG |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| InChI Key | UYTUWBDQBGRXJP-SOZMHADISA-N |
| Smiles | O=C(N[C@@H](CCC(N)=O)C(NCC(N[C@@H]([C@H](O)C)C(N[C@@H](CC1=CC=CC=C1)C(N2[C@@H](CCC2)C(N[C@@H](CC(O)=O)C(NCC(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CC(C)C)C(N[C@@H](CC4=CNC5=CC=CC=C45)C(N[C@@H](C)C(N[C@@H](C(C)C)C(NCC(N[C@@H](CO)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CC6=CC=C(C=C6)O)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(O)=O)C(NCC(NCC(N[C@@H](CC7=CNC8=CC=CC=C78)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC9=CNC=N9)C(NCC(N[C@@H](CCCCN)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC%10=CC=CC=C%10)N |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Klotho-derived peptide 1
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for Klotho-derived peptide 1
References for Klotho-derived peptide 1
References are publications that support the biological activity of the product.
Yuan et al (2022) A Klotho-derived peptide protects against kidney fibrosis by targeting TGF-β signaling. Nat.Commun. 13 438 PMID: 35064106
If you know of a relevant reference for Klotho-derived peptide 1, please let us know.
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Keywords: Klotho-derived peptide 1, Klotho-derived peptide 1 supplier, TGF-βRII, TGF-β, TGF-betaRII, TGFbRII, TGFbR2, Kinases, Transforming, Growth, Factors, Beta, Receptors, TGF-beta, RSTK, Receptor, Serine/Threonine, RSTKs, KP1, renal, fibrosis, kidney, in, vivo, 7830, Tocris Bioscience
Citations for Klotho-derived peptide 1
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Pathways for Klotho-derived peptide 1
