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Submit ReviewKY 02111
Description: Inhibits canonical Wnt signaling. Promotes differentiation of human ESCs and iPSCs into cardiomyocytes
Chemical Name: N-(6-Chloro-2-benzothiazolyl)-3,4-dimethoxybenzenepropanamide
Purity: ≥98% (HPLC)
Biological Activity for KY 02111
KY 02111 promotes differentiation of human ESCs and iPSCs into cardiomyocytes when used after day three in culture; differentiation efficiency increases when used after initial culture with CHIR 99021 (Cat. No. 4423). Induces downregulation of Wnt signaling target genes; inhibits canonical Wnt signaling in a manner distinct from other known Wnt inhibitors.
Compound Libraries for KY 02111
KY 02111 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.
Technical Data for KY 02111
| M. Wt | 376.86 |
| Formula | C18H17ClN2O3S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1118807-13-8 |
| PubChem ID | 8582409 |
| InChI Key | LXFKEVQQSKQXPR-UHFFFAOYSA-N |
| Smiles | O=C(CCC3=CC=C(OC)C(OC)=C3)NC2=NC1=CC=C(Cl)C=C1S2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for KY 02111
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 18.84 | 50 |
Preparing Stock Solutions for KY 02111
The following data is based on the product molecular weight 376.86. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.31 mL | 26.54 mL | 53.07 mL |
| 2.5 mM | 1.06 mL | 5.31 mL | 10.61 mL |
| 5 mM | 0.53 mL | 2.65 mL | 5.31 mL |
| 25 mM | 0.11 mL | 0.53 mL | 1.06 mL |
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Product Datasheets for KY 02111
References for KY 02111
References are publications that support the biological activity of the product.
Minami et al (2012) A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions. Cell Rep. 2 1448 PMID: 23103164
If you know of a relevant reference for KY 02111, please let us know.
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Keywords: KY 02111, KY 02111 supplier, KY02111, stem, cell, differentiation, cardiomyocytes, human, iPSCs, ESCs, Wnt, signaling, pathway, inhibits, inhibitors, Other, Signaling, Cardiomyocyte, Stem, Cells, and, iPSC, 4731, Tocris Bioscience
2 Citations for KY 02111
Citations are publications that use Tocris products. Selected citations for KY 02111 include:
Qui et al (2017) Rapamycin and CHIR99021 coordinate robust cardiomyocyte differentiation from human pluripotent stem cells via reducing p53-dependent apoptosis. J.Am.Heart Assoc. 6 e005295 PMID: 28971953
Chris et al (2020) Variable expression and silencing of CRISPR-Cas9 targeted transgenes identifies the AAVS1 locus as not an entirely safe harbour. F1000Res 8 1911 PMID: 32789000
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Literature in this Area
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Stem Cell Research Product Guide
This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:
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- GMP and Ancillary Material Grade Products
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem Cell Workflow Poster
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.