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KYA 1797K

Cat. No. 7002 Submit a Review Datasheet / COA / SDS
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Description: Wnt/β-catenin signaling inhibitor
Chemical Name: (5Z)-5-[[5-(4-Nitrophenyl)-2-furanyl]methylene]-4-oxo-2-thioxo-3-thiazolidinepropanoic acid potassium salt
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for KYA 1797K

KYA 1797K is a Wnt/β-catenin signaling inhibitor (IC50 = 0.75 μM). Increases binding affinity of β-catenin for axin, GSK-3β and β-TrCP. Promotes formation of the destruction complex, activation of GSK-3β and phosphorylation of β-catenin and K-Ras, leading to their degradation via the ubiquitin/proteasome system. Reduces levels of β-catenin and K-Ras and inhibits growth of colorectal cancer (CRC) cells in vitro and in mouse xenograft models.

Technical Data for KYA 1797K

M. Wt 442.5
Formula C17H11KN2O6S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1956356-56-1
PubChem ID 119057297
InChI Key PHUNRLYHXGMOLG-WQRRWHLMSA-M
Smiles C1=CC(=CC=C1C2=CC=C(O2)/C=C\3/C(=O)N(C(=S)S3)CCC(=O)[O-])[N+](=O)[O-].[K+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for KYA 1797K

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 2.21 5 with gentle warming

Preparing Stock Solutions for KYA 1797K

The following data is based on the product molecular weight 442.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 45.2 mL 225.99 mL 451.98 mL
0.25 mM 9.04 mL 45.2 mL 90.4 mL
0.5 mM 4.52 mL 22.6 mL 45.2 mL
2.5 mM 0.9 mL 4.52 mL 9.04 mL

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References for KYA 1797K

References are publications that support the biological activity of the product.

Cha et al (2016) Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation. Nat.Chem.Biol. 12 593 PMID: 27294323

Park et al (2019) A Ras destabilizer KYA1797K overcomes the resistance of EGFR tyrosine kinase inhibitor in KRAS-mutated non-small cell lung cancer. Sci.Rep. 9 648 PMID: 30679620

If you know of a relevant reference for KYA 1797K, please let us know.

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Citations for KYA 1797K

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Pathways for KYA 1797K

Wnt Signaling Pathway

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.