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Submit ReviewL-670,596
Description: Potent, selective thromboxane A2/prostaglandin endoperoxide antagonist
Chemical Name: (-)-6-8-Difluoro-2,3,4,9-tetrahydro-9-[[4-(methylsulfonyl)phenyl]methyl]-1H-carbazole-1-acetic acid
Purity: ≥98% (HPLC)
Biological Activity for L-670,596
L-670,596 is a potent and selective thromboxane A2/prostaglandin endoperoxide receptor antagonist (IC50 = 5.5 nM). Inhibits U-44069-induced contractions of guinea pig trachea (pA2 = 9.0) and human platelet aggregation in vitro (IC50 = 6.5 nM). Also prevents thromboxane-mediated endothelial cell death. Orally active in vivo.
Technical Data for L-670,596
| M. Wt | 433.47 |
| Formula | C22H21F2NO4S |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 121083-05-4 |
| PubChem ID | 129360 |
| InChI Key | GMJWAIMJHBTYPD-UHFFFAOYSA-N |
| Smiles | CS(=O)(=O)C1=CC=C(CN2C3=C(CCCC3CC(O)=O)C3=CC(F)=CC(F)=C23)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for L-670,596
References for L-670,596
References are publications that support the biological activity of the product.
Ford-Hutchinson et al (1989) The pharmacology of L-670,596, a potent and selective thromboxane/prostaglandin endoperoxide receptor antagonist. Can.J.Physiol.Pharmacol. 67 989 PMID: 2598135
Girard et al (1989) Tetrahydrocarbazol-1-acetic acids: new class of thromboxane receptor antagonists. Prog.Clin.Biol.Res. 301 585 PMID: 2529558
Beauchamp et al (2001) Role of thromboxane in retinal microvascular degeneration in oxygen-induced retinopathy. J.Appl.Physiol. 90 2279 PMID: 11356793
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Keywords: L-670,596, L-670,596 supplier, Potent, selective, thromboxane, A2, endoperoxide, antagonists, TP, TXA2, Prostanoid, prostaglandins, prostacyclins, eicosanoids, L670596, Receptors, 1949, Tocris Bioscience
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