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Submit ReviewL-690,488
Description: Cell permeable prodrug of the IMPase inhibitor L-690,330 (Cat. No. 0681)
Chemical Name: 1-[(4-Hydroxyphenoxy)ethylidene]bis[phosphinylidynebis(oxymethylene)]-2,2-dimethylpropanoate
Purity: ≥98% (HPLC)
Biological Activity for L-690,488
L-690,488 is a cell-permeable prodrug of the potent inositol monophosphatase inhibitor L-690,330 (Cat. No. 0681); penetrates cells more effectively than its metabolite.
Licensing Information
Sold with the permission of Merck Sharp and Dohme Ltd.
Technical Data for L-690,488
| M. Wt | 754.7 |
| Formula | C32H52O16P2 |
| Storage | Store at -80°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 142523-14-6 |
| PubChem ID | 5132514 |
| InChI Key | LOTSPVPQHAUHCE-UHFFFAOYSA-N |
| Smiles | OC1=CC=C(OC(P(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)=O)(C)P(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for L-690,488
References for L-690,488
References are publications that support the biological activity of the product.
Atack et al (1994) Effects of L-690,488, a prodrug of the bisphosphonate inositol monophosphatase inhibitor L-690,330, on phosphatidylinositol cycle markers. J.Pharmacol.Exp.Ther. 270 70 PMID: 8035344
Chen et al (1998) Stimulatory effect of Li on glucose transport in rat adipocytes is not mediated by elevation of IP1. Am.J.Physiol. 275 E272 PMID: 9688629
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Keywords: L-690,488, L-690,488 supplier, Inositol, monophosphatase, inhibitors, inhibits, PIP2, Lipids, Ins145P3, 5-Phosphatase, IMPase, Phosphatases, L690488, 0682, Tocris Bioscience
1 Citation for L-690,488
Citations are publications that use Tocris products. Selected citations for L-690,488 include:
Harding et al (2013) LtpD is a novel Legionella pneumophila effector that binds phosphatidylinositol 3-phosphate and inositol monophosphatase IMPA1. Mol Cancer 81 4261 PMID: 24002062
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