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Submit ReviewL-694,247
Description: 5-HT1D agonist
Chemical Name: 2-[5-[3-(4-Methylsulfonylamino)benzyl-1,2,4-oxadiazol-5-yl]-1H-indol-3-yl]ethanamine
Purity: ≥98% (HPLC)
Biological Activity for L-694,247
L-694,247 is a selective and extremely potent 5-HT1D receptor agonist.
Licensing Information
Sold with the permission of Merck Sharp and Dohme Ltd.
Technical Data for L-694,247
| M. Wt | 411.48 |
| Formula | C20H21N5O3S |
| Storage | Desiccate at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 137403-12-4 |
| PubChem ID | 132059 |
| InChI Key | HKXMQLISPYELRD-UHFFFAOYSA-N |
| Smiles | CS(=O)(=O)NC1=CC=C(CC2=NOC(=N2)C2=CC=C3NC=C(CCN)C3=C2)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for L-694,247
References for L-694,247
References are publications that support the biological activity of the product.
Beer et al (1993) L-694,247: a potent 5-HT1D receptor agonist. Br.J.Pharmacol. 110 1196 PMID: 8298808
Buhlen et al (1996) Evidence for presynaptic location of inhibitory 5-HT1Dβ -like autoreceptors in the guinea-pig brain cortex. Naunyn Schmiedebergs Arch.Pharmacol. 353 281 PMID: 8692282
Heald et al (1994) [3H]L-694,247 labels the 5-HT1Dβ receptor in pig caudate membranes. Eur.J.Pharmacol. 264 213 PMID: 7851485
Street et al (1993) Synthesis and serotonergic activity of 5-(oxadiazoyl)tryptamines: potent agonists of 5-HT1D receptors. J.Med.Chem. 36 1529 PMID: 8496922
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Keywords: L-694,247, L-694,247 supplier, 5-HT1D, agonists, Serotonin, Receptors, L694247, merck, 0781, Tocris Bioscience
3 Citations for L-694,247
Citations are publications that use Tocris products. Selected citations for L-694,247 include:
Hampson et al (2007) Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs. Diabetologia 50 1743 PMID: 17579833
Bhalla et al (2001) Molecular cloning, pharmacological properties and tissue distribution of the porcine 5-HT(1B) receptor. Br J Pharmacol 133 891 PMID: 11454663
Geerts et al (1999) Involvement of 5-HT1B receptors in collar-induced hypersensitivity to 5-hydroxytryptamine of the rabbit carotid artery. Br J Pharmacol 127 1327 PMID: 10455282
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.