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Submit ReviewL-703,664 succinate
Description: Selective 5-HT1D agonist
Chemical Name: N,N-Dimethyl-5-[(5-methyl-1,1-dioxodo-1,2,5-thiadiazolidin-2-yl)methyl]-1H-indole-3-ethanamine succinate
Purity: ≥99% (HPLC)
Biological Activity for L-703,664 succinate
L-703,664 succinate is a 5-HT1D receptor agonist that displays selectivity over other 5-HT receptor subtypes (pIC50 values are 7.2, 6.1, < 5.0 and < 5.0 for 5-HT1D, 5-HT1A, 5-HT2A and 5-HT3 respectively) and other receptors (pIC50 < 5.0 for adenosine, adrenergic, excitatory amino acids, dopamine, histamine, muscarinic, nicotinic and opiate receptors).
Licensing Information
Sold with the permission of Merck, Sharpe and Dohme Ltd.
Technical Data for L-703,664 succinate
| M. Wt | 454.54 |
| Formula | C16H24N4O2S.C4H6O4 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 144776-01-2 |
| PubChem ID | 90488774 |
| InChI Key | WLXRLNXDMGIORD-UHFFFAOYSA-N |
| Smiles | O=S1(N(CCN1C)CC2=CC=C(NC=C3CCN(C)C)C3=C2)=O.O=C(CCC(O)=O)O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for L-703,664 succinate
References for L-703,664 succinate
References are publications that support the biological activity of the product.
Castro et al (1994) Synthesis and biological activity of 3-[2-(dimethylamino)ethyl]-5-[(1,1-dioxo-5-methyl-1,2,5-thiadiazolidin-2-yl)-methyl]-1H-indole and analogues: agonists for the 5-HT1D receptor. J.Med.Chem. 37 3023 PMID: 7932524
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Keywords: L-703,664 succinate, L-703,664 succinate supplier, Selective, 5-HT1D, receptor, agonists, Serotonin, Receptors, L703664, 2640, Tocris Bioscience
Citations for L-703,664 succinate
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Currently there are no citations for L-703,664 succinate.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.