Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewL002
Description: p300 inhibitor
Chemical Name: 4-[O-[(4-Methoxyphenyl)sulfonyl]oxime]-2,6-dimethyl-2,5-cyclohexadiene-1,4-dione
Purity: ≥98% (HPLC)
Biological Activity for L002
L002 is a p300 inhibitor (IC50 = 1.98 μM). Inhibits histone and p53 acetylation, and suppresses STAT3 activation in cell-based assays. Also suppresses tumor growth in a mouse MDA-MB-468 xenograft model.
Technical Data for L002
| M. Wt | 321.35 |
| Formula | C15H15NO5S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 321695-57-2 |
| PubChem ID | 2221149 |
| InChI Key | VEWFTYOFWIXCIO-UHFFFAOYSA-N |
| Smiles | O=C(C(C)=C2)C(C)=C\C2=N/OS(C1=CC=C(OC)C=C1)(=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for L002
References for L002
References are publications that support the biological activity of the product.
Yang et al (2013) Small-molecule inhibitors of acetyltransferase p300 identified by high-throughput screening are potent anticancer agents. Mol.Cancer Ther. 12 610 PMID: 23625935
View Related Products by Target
View Related Products by Product Action
Keywords: L002, L002 supplier, p300, EP300, lysine, histone, acetyltransferases, inhibitors, inhibits, HATs, anticancer, Histone, Acetyltransferases, Post-translational, Modifications, 5045, Tocris Bioscience
Citations for L002
Citations are publications that use Tocris products.
Currently there are no citations for L002.
Reviews for L002
There are currently no reviews for this product. Be the first to review L002 and earn rewards!
Have you used L002?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.