Latrunculin B

Cat. No. 3974 5 Citations Submit a Review Datasheet / COA / SDS

Pricing	Availability		Qty

Description: Inhibitor of actin polymerization

Chemical Name: (4R)-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-2-thiazolidinone

Purity: ≥95% (HPLC)

Datasheet

Citations (5)

Reviews

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Latrunculin B

Latrunculin B is an inhibitor of actin polymerization. Interacts with G-actin in a 1:1 ratio to inhibit polymerization into F-actin in vitro (IC₅₀ values are ~60 and ~900 nM in absence and presence of calf serum, respectively). Marine toxin.

Technical Data for Latrunculin B

M. Wt	395.51
Formula	C₂₀H₂₉NO₅S
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	76343-94-7
PubChem ID	3892
InChI Key	NSHPHXHGRHSMIK-UHFFFAOYSA-N
Smiles	O=C1/C=C(C)\CC/C=C\[C@@H](C)CC[C@@H]2C[C@H](C[C@](O)([C@@]3([H])NC(SC3)=O)O2)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Latrunculin B

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	19.78	50
	ethanol	19.78	50

Preparing Stock Solutions for Latrunculin B

The following data is based on the product molecular weight 395.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.06 mL	25.28 mL	50.57 mL
2.5 mM	1.01 mL	5.06 mL	10.11 mL
5 mM	0.51 mL	2.53 mL	5.06 mL
25 mM	0.1 mL	0.51 mL	1.01 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

Product Datasheets for Latrunculin B

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for Latrunculin B

References are publications that support the biological activity of the product.

Wakatsuki et al (2001) Effects of cytochalasin D and latrunculin B on mechanical properties of cells. J.Cell.Sci. 114 1025 PMID: 11181185

If you know of a relevant reference for Latrunculin B, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Actin Inhibitors

Keywords: Latrunculin B, Latrunculin B supplier, Inhibitors, Inhibits, Actin, filament, modulator, G-Actin, F-Actin, monomers, polymers, toxin, 3974, Tocris Bioscience