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Submit ReviewLEP (116-130) (mouse)
Description: Synthetic leptin peptide fragment
Biological Activity for LEP (116-130) (mouse)
LEP (116-130) (mouse) is a synthetic leptin peptide fragment. Restricts weight gain and reduces food intake in female mice lacking endogenously circulating active leptin.
Technical Data for LEP (116-130) (mouse)
| M. Wt | 1560.73 |
| Formula | C64H109N19O24S |
| Sequence |
SCSLPQTSGLQKPES (Modifications: Ser-15 = C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 258276-95-8 |
| PubChem ID | 90471193 |
| InChI Key | YEHDWBRMEXDYLT-RDEOYNLOSA-N |
| Smiles | [H]N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for LEP (116-130) (mouse)
References for LEP (116-130) (mouse)
References are publications that support the biological activity of the product.
Grasso et al (1997) In vivo effects of leptin-related synthetic peptides on body weight and food intake in female ob/ob mice: localization of leptin activity to domains between amino acid residues 106-140. Endocrinology 138 1413 PMID: 9075696
Grasso et al (1999) Inhibitory effects of leptin-related synthetic peptide 116-130 on food intake and body weight gain in female C57BL/6J ob/ob mice may not be mediated by peptide activation of the long isoform of the leptin receptor. Diabetes 48 2204 PMID: 10535455
Rozhavskaya et al (2000) Design of a synthetic leptin agonist: effects on energy balance, glucose homeostasis and thermoregulation. Endocrinology 141 2501 PMID: 10875251
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Keywords: LEP (116-130) (mouse), LEP (116-130) (mouse) supplier, Synthetic, leptin, peptide, fragment, Receptors, adipokines, Leptin, 2985, Tocris Bioscience
Citations for LEP (116-130) (mouse)
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Gut Hormones Poster
The gastrointestinal tract is the largest endocrine gland in the human body, secreting hormones that affect digestion, appetite and energy expenditure. Neuropeptide modulators and gut hormones that influence appetite are reviewed in this poster.