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Leukadherin 1

Cat. No. 4921 Submit a Review Datasheet / COA / SDS

Discontinued Product

4921 has been discontinued.

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Description: Allosteric activator of CD11b/CD18
Chemical Name: 4-[(5-[[4-Oxo-3-(phenylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]benzoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Datasheets References

Biological Activity for Leukadherin 1

Leukadherin 1 is an allosteric activator of CD11b/CD18. Increases CD11b/CD18-dependent cell adhesion to fibrinogen (EC50 = 4 μM). Decreases leukocyte motility and transendothelial migration; reduces inflammation. Also activates complement receptor 3 (CR3), and promotes CR3-dependent leukocyte adhesion to fibrinogen-coated surfaces.

Technical Data for Leukadherin 1

M. Wt 421.49
Formula C22H15NO4S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 344897-95-6
PubChem ID 5342077
InChI Key AEZGRQSLKVNPCI-UNOMPAQXSA-N
Smiles S=C(N(CC3=CC=CC=C3)C2=O)S/C2=C\C1=CC=C(C4=CC=C(C(O)=O)C=C4)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Leukadherin 1

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for Leukadherin 1

References are publications that support the biological activity of the product.

Maiguel et al (2011) Small molecule-mediated activation of the integrin CD11b/CD18 reduces inflammatory disease. Sci.Signal. 4 1 PMID: 21900205

Reed et al (2013) Complement receptor 3 influences Toll-like receptor 7/8-dependent inflammation. J.Biol.Chem. 288 9077 PMID: 23386618

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Keywords: Leukadherin 1, Leukadherin 1 supplier, anti-inflammatory, anti-inflammatories, inflammation, leukocyte, extravasation, trans-endothelial, migration, adhesion, CD11b/CD18, activators, allosteric, integrins, Integrins, Cell, Adhesion, Molecules, 4921, Tocris Bioscience

Citations for Leukadherin 1

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Currently there are no citations for Leukadherin 1.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Enabling Research By Provision of Chemical Tools Poster

Enabling Research By Provision of Chemical Tools Poster

The Tocris chemistry team has considerable chemistry knowledge and skill which it has recently been applying to the generation of new chemical probes from known tools and compounds to help answer biological questions. This poster presents some of the work carried out by Tocris scientists and focuses on two areas: the generation of libraries of chemical building blocks to support Degrader (PROTAC) research and the development of a fluorescent probe to study integrin biology. Presented at Chemical Tools for Complex Biological Systems II, 2019, Janelia Research Campus, USA.