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Linifanib

Cat. No. 7743 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent inhibitor of PDGFRβ, KDR, FLT3 and CSF-1R
Chemical Name: N-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Linifanib

Linifanib is a potent receptor tyrosine kinase (RTK) inhibitor. It inhibits PDGFRβ, KDR, FLT3, CSF-1R (IC50 values are 2, 4, 4 and 7 nM, respectively). Linifanib inhibits angiogenesis in vascularized micro-organs and potently inhibits VEGF-stimulated endothelial cell proliferation (IC50 = 0.2 nM). Linifanib also promotes the generation and reprogramming of iPSCs from somatic cells.

Technical Data for Linifanib

M. Wt 375.4
Formula C21H18FN5O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 796967-16-3
PubChem ID 11485656
InChI Key MPVGZUGXCQEXTM-UHFFFAOYSA-N
Smiles O=C(NC=1C=CC(=CC1)C=2C=CC=C3NN=C(N)C32)NC4=CC(=CC=C4F)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Linifanib

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 7.51 20
DMSO 37.54 100

Preparing Stock Solutions for Linifanib

The following data is based on the product molecular weight 375.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.66 mL 13.32 mL 26.64 mL
5 mM 0.53 mL 2.66 mL 5.33 mL
10 mM 0.27 mL 1.33 mL 2.66 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

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References for Linifanib

References are publications that support the biological activity of the product.

Albert et al (2006) Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor. Mol.Cancer Ther. 5 995 PMID: 16648571

Guan et al (2022) Chemical reprogramming of human somatic cells to pluripotent stem cells. Nature 605 325 PMID: 35418683

Jahid et al (2022) Structure-based design of CDC42 effector interaction inhibitors for the treatment of cancer. Cell Rep. 39 110641 PMID: 35385746

If you know of a relevant reference for Linifanib, please let us know.

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Citations for Linifanib

Citations are publications that use Tocris products.

Currently there are no citations for Linifanib. Do you know of a great paper that uses Linifanib from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.