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Submit ReviewLM 22A4
Description: Potent TrkB agonist
Chemical Name: N,N',N''Tris(2-hydroxyethyl)-1,3,5-benzenetricarboxamide
Purity: ≥98% (HPLC)
Biological Activity for LM 22A4
LM 22A4 is a potent tropomyosin-related kinase B (TrkB) agonist. Induces activation of Trk, Akt and ERK in mouse hippocampus and striatum and exhibits neurotrophic activity. Reverses deficits in motor task learning in mice following traumatic brain injury; restores respiratory function in a rat model of Rett syndrome.
Compound Libraries for LM 22A4
LM 22A4 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for LM 22A4
| M. Wt | 339.34 |
| Formula | C15H21N3O6 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 37988-18-4 |
| PubChem ID | 2054170 |
| InChI Key | RGWJKANXFYJKHN-UHFFFAOYSA-N |
| Smiles | O=C(NCCO)C1=CC(C(NCCO)=O)=CC(C(NCCO)=O)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for LM 22A4
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.93 | 100 | |
| water | 33.93 | 100 |
Preparing Stock Solutions for LM 22A4
The following data is based on the product molecular weight 339.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.95 mL | 14.73 mL | 29.47 mL |
| 5 mM | 0.59 mL | 2.95 mL | 5.89 mL |
| 10 mM | 0.29 mL | 1.47 mL | 2.95 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.59 mL |
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Product Datasheets for LM 22A4
References for LM 22A4
References are publications that support the biological activity of the product.
Massa et al (2010) Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents. J.Clin.Invest. 120 1774 PMID: 20407211
Schmid et al (2012) A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome. J.Neurosci. 32 1803 PMID: 22302819
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Keywords: LM 22A4, LM 22A4 supplier, LM22A4, tropomyosin, related, kinases, B, TrkB, agonists, potent, Rett, syndrome, Trk, Receptors, 4607, Tocris Bioscience
2 Citations for LM 22A4
Citations are publications that use Tocris products. Selected citations for LM 22A4 include:
Garcia et al (2019) Huntington's Disease Patient-Derived Astrocytes Display Electrophysiological Impairments and Reduced Neuronal Support. Front Neurosci 13 669 PMID: 31316341
Al-Qudah et al (2014) Brain-derived neurotrophic factor enhances cholinergic contraction of longitudinal muscle of rabbit intestine via activation of phospholipase C. Am J Physiol Gastrointest Liver Physiol 306 G328 PMID: 24356881
Do you know of a great paper that uses LM 22A4 from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Huntington's Disease Poster
Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.