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LW 6

Cat. No. 6322 Submit a Review Datasheet / COA / SDS
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Description: Malate dehydrogenase-2 (MDH2) inhibitor; also inhibits HIF-1α
Alternative Names: CAY 10585
Chemical Name: Methyl 4-hydroxy-3-[[2-(4-tricyclo[3.3.1.13,7]dec-1-ylphenoxy)acetyl]amino]benzoate
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for LW 6

LW 6 is a malate dehydrogenase-2 (MDH2) inhibitor (IC50 = 6.3 μM). Also inhibits HIF-1α. Prevents accumulation of HIF-1α in Hep3B cells under hypoxic conditions (IC50 = 2.6 μM) with resulting decrease in expression of HIF-1α target genes VEGF and EPO. Inhibits proliferation of activated human T cells ex vivo.

Compound Libraries for LW 6

LW 6 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for LW 6

M. Wt 435.51
Formula C26H29NO5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 934593-90-5
PubChem ID 16124726
InChI Key BJRPPNOJYFZSLY-QXRPDJHGSA-N
Smiles O=C(C1=CC=C(C(NC(COC2=CC=C(C3(C[C@H](C4)C5)C[C@H]5C[C@H]4C3)C=C2)=O)=C1)O)OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for LW 6

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 21.78 50

Preparing Stock Solutions for LW 6

The following data is based on the product molecular weight 435.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.59 mL 22.96 mL 45.92 mL
2.5 mM 0.92 mL 4.59 mL 9.18 mL
5 mM 0.46 mL 2.3 mL 4.59 mL
25 mM 0.09 mL 0.46 mL 0.92 mL

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References for LW 6

References are publications that support the biological activity of the product.

Eleftheriadis et al (2015) Malate dehydrogenase-2 inhibitor LW6 promotes metabolic adaptations and reduces proliferation and apoptosis in activated human T-cells. Exp.Ther.Med. 5 1959 PMID: 26640580

Lee et al (2007) (Aryloxyacetylamino)benzoic acid analogues: A new class of hypoxia-inducible factor-1 inhibitors. J.Med.Chem. 50 1675 PMID: 17328532

Ban et al (2016) A novel malate dehydrogenase 2 inhibitor suppresses hypoxia-inducible factor-1 by regulating mitochondrial respiration. PLoS One 9 e0162568 PMID: 27611801

If you know of a relevant reference for LW 6, please let us know.

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Citations for LW 6

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