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Description: Selective, competitive BLT2 receptor antagonist
Chemical Name: 1-[5-Ethyl-2-hydroxy-4-[[6-methyl-6-(1H-tetrazol-5-yl)heptyl]oxy]phenyl]ethanone
Purity: ≥98% (HPLC)
Biological Activity for LY 255283
LY 255283 is a selective, competitive antagonist of BLT2 receptors (IC50 values are ~ 1 and > 10 μM at human recombinant BLT2 and BLT1 receptors respectively). Inhibits LTB4-induced contraction of lung parenchyma (pA2 = 7.2), and reduces LTB4-mediated airway obstruction in guinea pigs following i.v. and oral administration..
Compound Libraries for LY 255283
LY 255283 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for LY 255283
| M. Wt | 360.46 |
| Formula | C19H28N4O3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 117690-79-6 |
| PubChem ID | 122023 |
| InChI Key | WCGXJPFHTHQNJL-UHFFFAOYSA-N |
| Smiles | CCC1=C(OCCCCCC(C)(C)C2=NN=NN2)C=C(O)C(=C1)C(C)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for LY 255283
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.05 | 100 | |
| ethanol | 9.01 | 25 |
Preparing Stock Solutions for LY 255283
The following data is based on the product molecular weight 360.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.77 mL | 13.87 mL | 27.74 mL |
| 5 mM | 0.55 mL | 2.77 mL | 5.55 mL |
| 10 mM | 0.28 mL | 1.39 mL | 2.77 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.55 mL |
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Product Datasheets for LY 255283
References for LY 255283
References are publications that support the biological activity of the product.
Herron et al (1992) Leukotriene B4 receptor antagonists: the LY255283 series of hydroxyacetophenones. J.Med.Chem. 35 1818 PMID: 1316967
Silbaugh et al (1992) Pulmonary actions of LY255283, a leukotriene B4 receptor antagonist. Eur.J.Pharmacol. 223 57 PMID: 1335877
Yokomizo et al (2001) Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2. J.Biol.Chem. 276 12454 PMID: 11278893
If you know of a relevant reference for LY 255283, please let us know.
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Keywords: LY 255283, LY 255283 supplier, Selective, competitive, BLT2, receptor, antagonists, CysLT1, Receptors, CysLT2, BLT1, OXE, Oxoeicosanoid, receptors, LTD4, LTE4, leukotrienes, eicosanoids, LY255283, Leukotriene, and, Related, 2208, Tocris Bioscience
1 Citation for LY 255283
Citations are publications that use Tocris products. Selected citations for LY 255283 include:
Cabral et al (2015) Leukotriene D4-induced Caco-2 cell proliferation is mediated by prostaglandin E2 synthesis. PLoS One 3 PMID: 26216432
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