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Submit ReviewLY 266097 hydrochloride
Description: Selective 5-HT2B antagonist
Chemical Name: 1-[(2-Chloro-3,4-dimethoxyphenyl)methyl]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-b]indole hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for LY 266097 hydrochloride
LY 266097 hydrochloride is a selective 5-HT2B receptor antagonist (pKi = 9.3). More than 100-fold selective over 5-HT2A and 5-HT2C. Attenuates amphetamine-induced locomotion in the rat.
Compound Libraries for LY 266097 hydrochloride
LY 266097 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for LY 266097 hydrochloride
| M. Wt | 407.33 |
| Formula | C21H23ClN2O2.HCl |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 172895-39-5 |
| PubChem ID | 9953184 |
| InChI Key | KPXKZZURYAXZQE-UHFFFAOYSA-N |
| Smiles | CC1=CC=C(NC3=C2CCNC3CC4=CC=C(OC)C(OC)=C4Cl)C2=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for LY 266097 hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.73 | 100 | |
| ethanol | 40.73 | 100 |
Preparing Stock Solutions for LY 266097 hydrochloride
The following data is based on the product molecular weight 407.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.46 mL | 12.28 mL | 24.55 mL |
| 5 mM | 0.49 mL | 2.46 mL | 4.91 mL |
| 10 mM | 0.25 mL | 1.23 mL | 2.46 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.49 mL |
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Product Datasheets for LY 266097 hydrochloride
References for LY 266097 hydrochloride
References are publications that support the biological activity of the product.
Audia et al (1996) Potent, selective tetrahydro-β-carboline antagonists of the serotonin 2B (5-HT2B) contractile receptor in the rat stomach fundus. J.Med.Chem. 39 2773 PMID: 8709108
Auclair et al (2010) The central serotonin2B receptor: a new pharmacological target to modulate the mesoaccumbens DArgic pathway activity. J.Neurochem. 114 1323 PMID: 20534001
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1 Citation for LY 266097 hydrochloride
Citations are publications that use Tocris products. Selected citations for LY 266097 hydrochloride include:
McCorvy et al (2018) Structural determinants of 5-HT2B receptor activation and biased agonism. Nat Struct Mol Biol 25 787 PMID: 30127358
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.