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Submit ReviewM 30 dihydrochloride
Description: Potent and non-selective MAO inhibitor; also an iron chelator and antioxidant
Chemical Name: N-(8-Hydroxy-5-quinolylmethyl)-N-methyl-2-propynylamine dihydrochloride
Purity: ≥98% (HPLC)
Biological Activity for M 30 dihydrochloride
M 30 dihydrochloride is a potent and brain selective monoamine oxidase (MAO) inhibitor (EC50 values are 37 and 57 nM for MAO-A and MAO-B, respectively). Also an iron chelator with antioxidant properties. Protects cells against 6-OHDA (Cat. No. 2547) induced apoptosis. Attenuates MPTP depletion of DA and increases striatal monoamine levels in a mouse Parkinson's disease model.
Technical Data for M 30 dihydrochloride
| M. Wt | 299.2 |
| Formula | C14H14N2O.2HCl |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 64821-19-8 |
| PubChem ID | 71311622 |
| InChI Key | XJNICPXVRPOSSO-UHFFFAOYSA-N |
| Smiles | CN(CC#C)CC1=C2C(N=CC=C2)=C(O)C=C1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for M 30 dihydrochloride
References for M 30 dihydrochloride
References are publications that support the biological activity of the product.
Zheng et al (2005) Novel potential neuroprotective agents with both iron chelating and amino acid-based derivatives targeting central nervous system neurons. Biochem.Pharmacol. 70 1642 PMID: 16226724
Zheng (2005) Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases: in vitro studies on antioxidant activity, prevention of lipid peroxide formation and monoamine oxidase inhibition. J.Neurochem. 95 68 PMID: 16181413
Gal et al (2005) Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases. In vivo selective brain monoamine oxidase inhibition and prevention of MPTP-induced striatal DA depletion. J.Neurochem. 95 79 PMID: 16181414
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Keywords: M 30 dihydrochloride, M 30 dihydrochloride supplier, M30, dihydrochloride, MAO, monoamine, oxidase, MAOA, MAOB, inhibitors, inhibits, non-selective, potent, antioxidant, iron, chelator, Monoamine, Oxidase, Antioxidants, Biochemicals, and, Molecular, Biology, 6067, Tocris Bioscience
1 Citation for M 30 dihydrochloride
Citations are publications that use Tocris products. Selected citations for M 30 dihydrochloride include:
Matthias et al (2022) Endogenously produced catecholamines improve the regulatory function of TLR9-activated B cells. PLoS Biol 20 e3001513 PMID: 35073310
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.