Home / Pharmacology / Enzymes / Esterases / Phospholipases / Phospholipase Activators / m-3M3FBS

m-3M3FBS

Cat. No. 1941 7 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Phospholipase C activator
Chemical Name: 2,4,6-Trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide
Purity: ≥98% (HPLC)
Datasheet
Citations (7)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for m-3M3FBS

m-3M3FBS is an activator of phospholipase C (PLC). Stimulates superoxide generation, Ca2+ release and inositol phosphate formation in a variety of cell types. Also inhibits growth of the leukemic cell lines U937 and THP-1.

Negative Control also available.

Compound Libraries for m-3M3FBS

m-3M3FBS is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for m-3M3FBS

M. Wt 343.36
Formula C16H16F3NO2S
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 200933-14-8
PubChem ID 761523
InChI Key ZIIUUSVHCHPIQD-UHFFFAOYSA-N
Smiles CC1=CC(C)=C(C(C)=C1)S(=O)(=O)NC1=CC=CC(=C1)C(F)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for m-3M3FBS

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 34.34 100
DMSO 34.34 100

Preparing Stock Solutions for m-3M3FBS

The following data is based on the product molecular weight 343.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.91 mL 14.56 mL 29.12 mL
5 mM 0.58 mL 2.91 mL 5.82 mL
10 mM 0.29 mL 1.46 mL 2.91 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for m-3M3FBS

References are publications that support the biological activity of the product.

Bae et al (2003) Identification of a compound that directly stimulates phospholipase C activity. Mol.Pharmacol. 63 1043 PMID: 12695532

Krjukova et al (2004) Phospholipase C activator m-3M3FBS affects Ca2+ homeostasis independently of phospholipase C activation. Br.J.Pharmacol. 143 3 PMID: 15302681

Lee et al (2005) The novel phospholipase C activator, m-3M3FBS, induces monocytic leukemia cell apoptosis. Cancer Lett. 222 227 PMID: 15863272

If you know of a relevant reference for m-3M3FBS, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Phospholipase Activators

Keywords: m-3M3FBS, m-3M3FBS supplier, Phospholipases, C, activators, activates, PLC, esterases, Phospholipase, Enzyme, Substrates, /, Activators, 1941, Tocris Bioscience

7 Citations for m-3M3FBS

Citations are publications that use Tocris products. Selected citations for m-3M3FBS include:

Shambharkar et al (2015) TMEM203 Is a Novel Regulator of Intracellular Calcium Homeostasis and Is Required for Spermatogenesis. PLoS One 10 e0127480 PMID: 25996873

Rioult-Pedotti et al (2015) DA Promotes Motor Cortex Plasticity and Motor Skill Learning via PLC Activation. J Gen Physiol 10 e0124986 PMID: 25938462

Semple-Rowland et al (2014) Activation of phospholipase C mimics the phase shifting effects of light on melatonin rhythms in retinal photoreceptors. PLoS One 8 e83378 PMID: 24386190

Hutchins et al (2013) Calcium release-dependent actin flow in the leading process mediates axophilic migration. PLoS One 33 11361 PMID: 23843509

Do you know of a great paper that uses m-3M3FBS from Tocris? Please let us know.

Reviews for m-3M3FBS

There are currently no reviews for this product. Be the first to review m-3M3FBS and earn rewards!

Have you used m-3M3FBS?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review