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Description: Phospholipase C activator
Chemical Name: 2,4,6-Trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide
Purity: ≥98% (HPLC)
Biological Activity for m-3M3FBS
m-3M3FBS is an activator of phospholipase C (PLC). Stimulates superoxide generation, Ca2+ release and inositol phosphate formation in a variety of cell types. Also inhibits growth of the leukemic cell lines U937 and THP-1.
Negative Control also available.
Compound Libraries for m-3M3FBS
m-3M3FBS is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for m-3M3FBS
| M. Wt | 343.36 |
| Formula | C16H16F3NO2S |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 200933-14-8 |
| PubChem ID | 761523 |
| InChI Key | ZIIUUSVHCHPIQD-UHFFFAOYSA-N |
| Smiles | CC1=CC(C)=C(C(C)=C1)S(=O)(=O)NC1=CC=CC(=C1)C(F)(F)F |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for m-3M3FBS
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 34.34 | 100 | |
| DMSO | 34.34 | 100 |
Preparing Stock Solutions for m-3M3FBS
The following data is based on the product molecular weight 343.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.91 mL | 14.56 mL | 29.12 mL |
| 5 mM | 0.58 mL | 2.91 mL | 5.82 mL |
| 10 mM | 0.29 mL | 1.46 mL | 2.91 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.58 mL |
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Product Datasheets for m-3M3FBS
References for m-3M3FBS
References are publications that support the biological activity of the product.
Bae et al (2003) Identification of a compound that directly stimulates phospholipase C activity. Mol.Pharmacol. 63 1043 PMID: 12695532
Krjukova et al (2004) Phospholipase C activator m-3M3FBS affects Ca2+ homeostasis independently of phospholipase C activation. Br.J.Pharmacol. 143 3 PMID: 15302681
Lee et al (2005) The novel phospholipase C activator, m-3M3FBS, induces monocytic leukemia cell apoptosis. Cancer Lett. 222 227 PMID: 15863272
If you know of a relevant reference for m-3M3FBS, please let us know.
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Keywords: m-3M3FBS, m-3M3FBS supplier, Phospholipases, C, activators, activates, PLC, esterases, Phospholipase, Enzyme, Substrates, /, Activators, 1941, Tocris Bioscience
7 Citations for m-3M3FBS
Citations are publications that use Tocris products. Selected citations for m-3M3FBS include:
Semple-Rowland et al (2014) Activation of phospholipase C mimics the phase shifting effects of light on melatonin rhythms in retinal photoreceptors. PLoS One 8 e83378 PMID: 24386190
Hutchins et al (2013) Calcium release-dependent actin flow in the leading process mediates axophilic migration. PLoS One 33 11361 PMID: 23843509
Carim et al (2019) IPIP27 Coordinates PtdIns(4,5)P2 Homeostasis for Successful Cytokinesis. Curr Biol 29 775 PMID: 30799246
Okada et al (2011) High extracellular Ca2+ stimulates Ca2+-activated Cl- currents in frog parathyroid cells through the mediation of arachidonic acid cascade. PLoS One 6 e19158 PMID: 21559478
Shambharkar et al (2015) TMEM203 Is a Novel Regulator of Intracellular Calcium Homeostasis and Is Required for Spermatogenesis. PLoS One 10 e0127480 PMID: 25996873
Rioult-Pedotti et al (2015) DA Promotes Motor Cortex Plasticity and Motor Skill Learning via PLC Activation. J Gen Physiol 10 e0124986 PMID: 25938462
Krjukova et al (2004) Phospholipase C activator m-3M3FBS affects Ca2+ homeostasis independently of phospholipase C activation. Br J Pharmacol 143 3 PMID: 15302681
Do you know of a great paper that uses m-3M3FBS from Tocris? Please let us know.
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