M4K2163 dihydrochloride

Cat. No. 7754 Submit a Review Datasheet / COA / SDS

Pricing	Availability		Qty

Description: Potent and selective ALK2 inhibitor

Chemical Name: 1-[4-[5-(4-Fluoro-3,5-dimethoxyphenyl)-4-methyl-3-pyridinyl]phenyl]piperazine dihydrochloride

Purity: ≥98% (HPLC)

Datasheet

Citations

Reviews

Literature (4)

Pathways (1)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for M4K2163 dihydrochloride

M4K2163 is a potent and selective activin receptor-like kinase 2 (ALK2) inhibitor (IC₅₀ values are 19 nM in vivo and 98 nM in vitro). Orally bioavailable and brain penetrant.

Technical Data for M4K2163 dihydrochloride

M. Wt	480.41
Formula	C₂₄H₂₆FN₃O₂.2HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2863635-04-3
InChI Key	HMNLQIQCOZETBK-UHFFFAOYSA-N
Smiles	FC1=C(OC)C=C(C2=CN=CC(C3=CC=C(N4CCNCC4)C=C3)=C2C)C=C1OC.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for M4K2163 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	48.04	100
	DMSO	48.04	100

Preparing Stock Solutions for M4K2163 dihydrochloride

The following data is based on the product molecular weight 480.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.08 mL	10.41 mL	20.82 mL
5 mM	0.42 mL	2.08 mL	4.16 mL
10 mM	0.21 mL	1.04 mL	2.08 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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Product Datasheets for M4K2163 dihydrochloride

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for M4K2163 dihydrochloride

References are publications that support the biological activity of the product.

Smil et al (2020) Leveraging an open science drug discovery model to develop CNS-penetrant ALK2 inhibitors for the treatment of diffuse intrinsic pontine glioma. J.Med.Chem. 63 10061 PMID: 32787083

Rooney and Jones (2021) Recent advances in ALK2 inhibitors. ACS Omega 6 20729 PMID: 34423181

If you know of a relevant reference for M4K2163 dihydrochloride, please let us know.

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Citations for M4K2163 dihydrochloride

Citations are publications that use Tocris products.

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Reviews for M4K2163 dihydrochloride

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Stem Cell Research Product Guide

This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:

Self-renewal and Maintenance
Differentiation
Reprogramming
Organoid Generation
GMP and Ancillary Material Grade Products

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Stem Cell Workflow Poster

Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.

Stem Cells Poster

Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.

Pathways for M4K2163 dihydrochloride

TGF-β Signaling Pathway

The TGF-β signaling pathway is involved in the regulation of growth and proliferation of cells along with migration, differentiation and apoptosis.