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Submit ReviewMA 2029
Description: Potent and selective, competitive motilin receptor antagonist; orally active
Chemical Name: 4-Fluoro-N-methyl-L-phenylalanyl-N-methyl-L-valyl-3-(1,1-dimethylethyl)-N-ethyl-L-tyrosinamide
Purity: ≥98% (HPLC)
Biological Activity for MA 2029
MA 2029 is a potent and selective, competitive motilin receptor antagonist (IC50 = 4.9 nM). Selective for the motilin receptor over a range of other receptors and ion channels. Inhibits motilin-induced duodenal muscle contractions in vitro. Also inhibits motilin-induced colonic and abdominal contractions in vivo. Orally active.
Technical Data for MA 2029
| M. Wt | 556.71 |
| Formula | C31H45FN4O4 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 287206-61-5 |
| PubChem ID | 10144175 |
| InChI Key | KSDWAJPUTRBIRR-KLJDGLGGSA-N |
| Smiles | FC1=CC=C(C[C@H](NC)C(N(C)[C@@H]([C@H](C)C)C(N[C@@H](CC2=CC=C(O)C(C(C)(C)C)=C2)[C@@](NCC)=O)=O)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for MA 2029
References for MA 2029
References are publications that support the biological activity of the product.
Sudo et al (2008) Oral administration of MA-2029, a novel selective and competitive motilin receptor antagonist, inhibits motilin-induced intestinal contractions and visceral pain in rabbits. Eur.J.Pharmacol. 581 296 PMID: 18164286
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Keywords: MA 2029, MA 2029 supplier, MA2029, potent, selective, competitive, motilin, receptors, antagonists, Motilin, Receptors, 4934, Tocris Bioscience
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