Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewMCU i4
Description: Negative modulator of mitochondrial Ca2+ uniporter (MCU)
Chemical Name: 4-[[4-(Diethylamino)phenyl]amino]-6-methyl-3-quinolinecarboxylic acid ethyl ester
Purity: ≥98% (HPLC)
Biological Activity for MCU i4
MCU i4 is a negative modulator of mitochondrial calcium (Ca2+) uniporter (MCU) complex, which binds to MICU1, a regulatory protein within MCU complex. MCU i4 reduces mitochondrial Ca2+ uptake in multiple cell lines including MEFs, MDA-MB,231 and HEK293T cells, and demonstrates a negative effect on mitochondrial membrane potential. In ex vivo muscle fibres, MCU i4 reduces mitochondrial Ca2+ uptake and impairs muscle cell growth.
Compound Libraries for MCU i4
MCU i4 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for MCU i4
| M. Wt | 377.49 |
| Formula | C23H27N3O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 371924-24-2 |
| PubChem ID | 1568449 |
| InChI Key | RIWXBJCWHVMATR-UHFFFAOYSA-N |
| Smiles | CCOC(=O)C1=C(NC2=CC=C(C=C2)N(CC)CC)C2=C(C=CC(C)=C2)N=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for MCU i4
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 18.87 | 50 | |
| ethanol | 37.75 | 100 |
Preparing Stock Solutions for MCU i4
The following data is based on the product molecular weight 377.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.65 mL | 13.25 mL | 26.49 mL |
| 5 mM | 0.53 mL | 2.65 mL | 5.3 mL |
| 10 mM | 0.26 mL | 1.32 mL | 2.65 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.53 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for MCU i4
References for MCU i4
References are publications that support the biological activity of the product.
Di Marco et al (2020) A high-throughput screening identifies MICU1 targeting compounds. Cell Rep. 30 2321 PMID: 32075766
If you know of a relevant reference for MCU i4, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: MCU i4, MCU i4 supplier, MCUi4, MCU, mitochondrial, calcium, ca2+, uniporter, complex, negative, modulators, inhibitors, inhibits, modulates, MICU1, Mitochondrial, Calcium, Uniporter, 7195, Tocris Bioscience
1 Citation for MCU i4
Citations are publications that use Tocris products. Selected citations for MCU i4 include:
Maria et al (2022) Mitochondria-Endoplasmic Reticulum Interplay Regulates Exo-Cytosis in Human Neuroblastoma Cells. Cells 11 PMID: 35159324
Do you know of a great paper that uses MCU i4 from Tocris? Please let us know.
Reviews for MCU i4
There are currently no reviews for this product. Be the first to review MCU i4 and earn rewards!
Have you used MCU i4?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image