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Submit ReviewMDL 72222
Description: 5-HT3 antagonist
Chemical Name: Tropanyl 3,5-dichlorobenzoate
Purity: ≥99% (HPLC)
Biological Activity for MDL 72222
MDL 72222 is a 5-HT3 antagonist.
Compound Libraries for MDL 72222
MDL 72222 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for MDL 72222
| M. Wt | 314.21 |
| Formula | C15H17Cl2NO2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 40796-97-2 |
| PubChem ID | 1683 |
| InChI Key | MNJNPLVXBISNSX-UHFFFAOYSA-N |
| Smiles | CN1C2CCC1CC(C2)OC(=O)C1=CC(Cl)=CC(Cl)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for MDL 72222
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 100 |
Preparing Stock Solutions for MDL 72222
The following data is based on the product molecular weight 314.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.18 mL | 15.91 mL | 31.83 mL |
| 5 mM | 0.64 mL | 3.18 mL | 6.37 mL |
| 10 mM | 0.32 mL | 1.59 mL | 3.18 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.64 mL |
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Product Datasheets for MDL 72222
References for MDL 72222
References are publications that support the biological activity of the product.
Fozard (1984) MDL 72222: a potent and highly selective antagonist at neuronal 5-hydroxytryptamine receptors. Naunyn Schmiedebergs Arch.Pharmacol. 326 36 PMID: 6472484
Richardson and Engel (1986) The pharmacology and function of 5-HT3 receptors. Trends Neurosci. 9 424
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Keywords: MDL 72222, MDL 72222 supplier, 5-HT3, antagonists, Serotonin, Receptors, MDL72222, 0640, Tocris Bioscience
6 Citations for MDL 72222
Citations are publications that use Tocris products. Selected citations for MDL 72222 include:
Bocchio et al (2015) Increased serotonin transporter expression reduces fear and recruitment of parvalbumin interneurons of the amygdala. Neuropsychopharmacology 40 3015 PMID: 26052039
Jinka et al (2012) Inhibition of NMDA-type glutamate receptors induces arousal from torpor in hibernating arctic ground squirrels (Urocitellus parryii). J Neurochem 122 934 PMID: 22697356
Dolma et al (2016) Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells. Cancer Cell 29 859 PMID: 27300435
Woo et al (2007) Neuregulin-1 enhances depolarization-induced GABA release. Neuron 54 599 PMID: 17521572
Hampson et al (2007) Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs. Diabetologia 50 1743 PMID: 17579833
Geerts et al (1999) Involvement of 5-HT1B receptors in collar-induced hypersensitivity to 5-hydroxytryptamine of the rabbit carotid artery. Br J Pharmacol 127 1327 PMID: 10455282
Do you know of a great paper that uses MDL 72222 from Tocris? Please let us know.
Reviews for MDL 72222
Average Rating: 5 (Based on 1 Review.)
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Pharmacological block of 5-HT3 receptors.
By
Anonymous on 08/31/2019
Assay Type: Ex Vivo
Species: Mouse
Cell Line/Tissue: Cerebellum
MDL 72222 was used for pharmacological isolation of glycine receptors response in nucleated membrane patches pulled from cerebellar granule cells. Clear response was obtained, with characteristic conductance states pertinent to glycine receptor. Picture: recording of single-channel openings of glycine receptor with 10 microM MDL 72222 in perfusion solution.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.