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Submit ReviewMEDICA 16
Description: FFA1 (GPR40) agonist; also inhibits ATP citrate lyase
Chemical Name: 3,3,14,14-Tetramethylhexadecanedioic acid
Biological Activity for MEDICA 16
MEDICA 16 is a free fatty acid 1 (FFA1/GPR40) receptor agonist; exhibits selectivity for FFA1 (GPR40) over GPR120. Also inhibits ATP citrate lyase; reduces intracellular triacylglycerol levels in muscle, inhibits lipogenesis and increases insulin sensitivity in rodents in vivo.
Technical Data for MEDICA 16
| M. Wt | 342.51 |
| Formula | C20H38O4 |
| Storage | Store at -20°C |
| CAS Number | 87272-20-6 |
| PubChem ID | 121871 |
| InChI Key | HYSMCRNFENOHJH-UHFFFAOYSA-N |
| Smiles | CC(CC(O)=O)(C)CCCCCCCCCCC(C)(C)CC(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for MEDICA 16
References for MEDICA 16
References are publications that support the biological activity of the product.
Hara et al (2009) Novel selective ligands for free fatty acid receptors GPR120 and GPR40. Naunyn Schmiedebergs Arch.Pharmacol. 380 247 PMID: 19471906
Atkinson et al (2002) MEDICA 16 inhibits hepatic acetyl-CoA carboxylase and reduces plasma triacylglycerol levels in Ins-resistant JCR:LA-cp rats. Diabetes 51 1548 PMID: 11978655
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Keywords: MEDICA 16, MEDICA 16 supplier, MEDICA16, free, fatty, acid, receptors, 1, FFA1, FFAR1, GPR40, agonists, ATP, citrate, lyases, inhibitors, inhibits, lipogenesis, insulin, sensitivity, triacylglyerol, synthases, transferases, ACLY, Free, Fatty, Acid, Receptors, Citrate, Lyase, 4615, Tocris Bioscience
Citations for MEDICA 16
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