Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewMelanotan II
Description: High affinity melanocortin receptor agonist
Alternative Names: MT-II
Purity: ≥95% (HPLC)
Biological Activity for Melanotan II
Melanotan II is a high affinity melanocortin receptor agonist (Ki values are 0.67, 6.6, 34 and 46 nM for MC1, MC4, MC3 and MC5 receptors respectively). Stimulates erectile activity, inhibits food intake and displays neuroprotective properties in vivo.
Technical Data for Melanotan II
| M. Wt | 1024.19 |
| Formula | C50H69N15O9 |
| Sequence |
XDHFRWK (Modifications: X = Nle & N-terminal Ac, Asp-2 = β-Asp, Phe-4 = D-Phe, Lys-7 = ε-Lys, Cyclized = Asp-2 - Lys-7, C-terminal amide) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 121062-08-6 |
| PubChem ID | 92432 |
| InChI Key | JDKLPDJLXHXHNV-MFVUMRCOSA-N |
| Smiles | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CC2=CC=CC=C2)NC(=O)[C@H](CC2=CNC=N2)NC1=O)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Melanotan II
| Solubility | Soluble to 0.70 mg/ml in water |
Product Datasheets for Melanotan II
References for Melanotan II
References are publications that support the biological activity of the product.
Martin et al (2002) Activation of melanocortin MC4 receptors increases erectile activity in rats ex copula. Eur.J.Pharmacol. 454 71 PMID: 12409007
Ter Laak et al (2003) The potent melanocortin receptor agonist melanotan-II promotes peripheral nerve regeneration and has neuroprotective properties in the rat. Eur.J.Pharmacol. 462 179 PMID: 12591111
Wikberg (1999) Melanocortin receptors: perspectives for novel drugs. Eur.J.Pharmacol. 375 295 PMID: 10443584
If you know of a relevant reference for Melanotan II, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Melanotan II, Melanotan II supplier, High, affinity, melanocortin, receptor, agonists, MC, Receptors, MelanotanII, MT-II, Melanocortin, 2566, Tocris Bioscience
1 Citation for Melanotan II
Citations are publications that use Tocris products. Selected citations for Melanotan II include:
Nøhr et al (2017) The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW. Neurochem Int 102 105 PMID: 27916541
Do you know of a great paper that uses Melanotan II from Tocris? Please let us know.
Reviews for Melanotan II
There are currently no reviews for this product. Be the first to review Melanotan II and earn rewards!
Have you used Melanotan II?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.