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Description: Potent, selective NK2 antagonist
Biological Activity for MEN 10376
MEN 10376 is a potent and selective NK2 receptor antagonist (pA2 = 8.08, rabbit pulmonary artery). Displays > 250-fold selectivity over NK1 (pA2 = 5.66, guinea pig ileum) and NK3 (Ki > 10 mM, guinea pig brain). Active in vivo.
Technical Data for MEN 10376
| M. Wt | 1081.24 |
| Formula | C57H68N12O10 |
| Sequence |
DYWVWWK (Modifications: Trp-3, Trp-5, Trp-6 = D-Trp, Lys-7 = C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 135306-85-3 |
| PubChem ID | 90479818 |
| InChI Key | QQHOFZNACVKNHK-JRPYWGABSA-N |
| Smiles | [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for MEN 10376
References for MEN 10376
References are publications that support the biological activity of the product.
Bartho et al (1992) Tachykininergic transmission to the circular muscle of the guinea-pig ileum: evidence for the involvement of NK2 receptors. Br.J.Pharmacol. 105 805 PMID: 1380373
Maggi et al (1991) In vivo evidence for tachykininergic transmission using a new NK-2 receptor-selective antagonist, MEN 10,376. J.Pharmacol.Exp.Ther. 257 1172 PMID: 1710662
Subramanian et al (1994) Pharmacological evidence of tachykinin-induced intracellular calcium rise in a human NK2 receptor transfected cell line. Biochem.Biophys.Res.Commun. 200 1512 PMID: 8185607
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Keywords: MEN 10376, MEN 10376 supplier, Potent, selective, NK2, antagonists, Tachykinin, Receptors, Neurokinin, MEN10376, Receptor, 1632, Tocris Bioscience
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