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Submit ReviewMephedrone hydrochloride
Description: Inhibits synaptosomal dopamine and 5-HT uptake
Chemical Name: (±)-2-Methylamino-1-(4-methylphenyl)propan-1-one hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Mephedrone hydrochloride
Inhibits striatal dopamine uptake and hippocampal 5-HT uptake in synaptosomes (IC50 values are 467 and 558 nM respectively). Administration causes a decrease in dopamine and 5-HT transporter function. Synthetic CNS stimulant; brain penetrant.
Technical Data for Mephedrone hydrochloride
| M. Wt | 213.7 |
| Formula | C11H15NO.HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 1189726-22-4 |
| PubChem ID | 46782120 |
| InChI Key | DLQZFTUKJGRPLZ-UHFFFAOYSA-N |
| Smiles | CC1=CC=C(C(C(C)NC)=O)C=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Mephedrone hydrochloride
References for Mephedrone hydrochloride
References are publications that support the biological activity of the product.
Hadlock et al (2011) 4-methylmethcathinone (mephedrone): neuropharmacological effects of a designer stimulant of abuse. J.Pharmacol.Exp.Ther. 339 530 PMID: 21810934
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Citations for Mephedrone hydrochloride
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.