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Submit ReviewMethoxyluteolin
Description: Inhibitor of pro-inflammatory mediator release from mast cells
Chemical Name: 2-(3,4-Dimethoxyphenyl)-5,7-dimethoxy-4H-1-benzopyran-4-one
Purity: ≥98% (HPLC)
Biological Activity for Methoxyluteolin
Methoxyluteolin inhibits release of pro-inflammatory mediators from mast cells and decreases gene expression and release of TNF, VEGF and IL-8/CXCL8. The product also significantly inhibits IL-33 stimulated expression and release of CCL5 and CCL2. Methoxyluteolin pretreatment of LAD2 mast cells decreases gene expression of TNF, CXCL8 and VEGF in response to neurotensin or substance P via mTOR activation.
Technical Data for Methoxyluteolin
| M. Wt | 342.35 |
| Formula | C19H18O6 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 855-97-0 |
| PubChem ID | 631170 |
| InChI Key | CLXVBVLQKLQNRQ-UHFFFAOYSA-N |
| Smiles | O=C1C=C(OC2=CC(OC)=CC(OC)=C12)C=3C=CC(OC)=C(OC)C3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Methoxyluteolin
References for Methoxyluteolin
References are publications that support the biological activity of the product.
Abubakr Bawazeer and Theoharides (2019) IL-33 stimulates human mast cell release of CCL5 and CCL2 via MAPK and NF-κB, inhibited by methoxyluteolin. Eur.J.Pharmacol. 865 PMID: 31669588
Weng et al (2015) The novel flavone tetramethoxyluteolin is a potent inhibitor of human mast cells. J.Allergy Clin.Immunol. 135 1044 PMID: 25498791
Patel and Theoharides (2017) Methoxyluteolin inhibits neuropeptide-stimulated proinflammatory mediator release via mTOR activation from human mast cells. J.Pharmacol.Exp.Ther. 361 462 PMID: 28404689
Taracanova et al (2018) Substance P and IL-33 administered together stimulate a marked secretion of IL-1β from human mast cells, inhibited by methoxyluteolin. Proc.Nat.Acad.Sci. USA 115 9381 PMID: 30232261
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Keywords: Methoxyluteolin, Methoxyluteolin supplier, methoxyluteolin, mast, cells, inhibitors, inhibits, cytokines, Cytokines, 7320, Tocris Bioscience
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