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Submit ReviewMG 624
Discontinued Product
1356 has been discontinued.
Description: α7 neuronal nAChR antagonist
Chemical Name: N,N,N-Triethyl-2-[4-(2-phenylethenyl)phenoxy]ethanaminium iodide
Purity: ≥98% (HPLC)
Biological Activity for MG 624
MG 624 is a selective antagonist for neuronal α7 subunit- containing nAChR subtypes. Inhibits α-Bgtx binding to chick α7 and α4β2 subtypes with Ki values of 106 nM and 84 μM respectively.
Technical Data for MG 624
| M. Wt | 451.39 |
| Formula | C22H30NOI |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 77257-42-2 |
| PubChem ID | 6433339 |
| InChI Key | RDTKUZXIHMTSJO-UEIGIMKUSA-M |
| Smiles | [I-].CC[N+](CC)(CC)CCOC1=CC=C(\C=C\C2=CC=CC=C2)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for MG 624
References for MG 624
References are publications that support the biological activity of the product.
Gotti et al (1998) 4-Oxystilbene compounds are selective ligands for neuronal nicotinic abungarotoxin receptors. Br.J.Pharmacol. 124 1197 PMID: 9720791
Maggi et al (1999) Selective effects of a 4-oxystilbene derivative on wild and mutant neuronal chick α7 nicotinic receptor. Br.J.Pharmacol. 126 285 PMID: 10051147
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Keywords: MG 624, MG 624 supplier, α7, alpha7, neuronal, nicotinic, receptor, antagonist, a7, Receptors, Acetylcholine, nAChR, MG624, Nicotinic, (a7), 1356, Tocris Bioscience
3 Citations for MG 624
Citations are publications that use Tocris products. Selected citations for MG 624 include:
Dolma et al (2016) Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells. Cancer Cell 29 859 PMID: 27300435
Cassilly et al (2016) SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A. Int J Clin Exp Pathol 11 e0154932 PMID: 27183222
Chang et al (2015) Protection against β-amyloid-induced synaptic and memory impairments via altering β-amyloid assembly by bis(heptyl)-cognitin. Sci Rep 5 10256 PMID: 26194093
Reviews for MG 624
Average Rating: 5 (Based on 1 Review.)
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The 5,760 bioactive compound library is a collated compound set of approved drugs and biologically active compound.
By
Anonymous on 02/01/2020
Assay Type: In Vitro
Species: Other
Biologically active compounds that have been documented to interact with awide range of targets including SB-224289 (Cat. # 1221), MG-624 (Cat.# 1356), GVIA (Cat. No. 1085), DPAT hydrobromide (Cat. No. 1080) and valinomycin (VA; Cat. # 3373) were ordered from Tocris Bioscience
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.
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