Milrinone

Discontinued Product

1504 has been discontinued.

View all Phosphodiesterases products.
Description: PDE3 inhibitor
Chemical Name: 1,6-Dihydro-2-methyl-6-oxo-(3,4'-bipyridine)-5-carbonitrile
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews

Biological Activity for Milrinone

Milrinone is a potent cAMP phosphodiesterase inhibitor (IC50 = 56 nM for inhibition of PDE III). Has inotropic and vasodilator effects following oral or intravenous administration in vivo.

Technical Data for Milrinone

M. Wt 211.22
Formula C12H9N3O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 78415-72-2
PubChem ID 4197
InChI Key PZRHRDRVRGEVNW-UHFFFAOYSA-N
Smiles CC1=C(C=C(C#N)C(=O)N1)C1=CC=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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Keywords: Milrinone, Milrinone supplier, PDE3, inhibitors, inhibits, Phosphodiesterases, 1504, Tocris Bioscience

2 Citations for Milrinone

Citations are publications that use Tocris products. Selected citations for Milrinone include:

Ørstavik et al (2015) The inotropic effect of the active metabolite of levosimendan, OR-1896, is mediated through inhibition of PDE3 in rat ventricular myocardium. Dent Res J (Isfahan) 10 e0115547 PMID: 25738589

Roberts et al (2010) Thrombospondin-1 induces platelet activation through CD36-dependent inhibition of the cAMP/protein kinase A signaling cascade. Blood 116 4297 PMID: 20664056


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