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Submit ReviewMitMAB
Description: Dynamin inhibitor
Chemical Name: Tetradecyltrimethylammonium bromide
Biological Activity for MitMAB
MitMAB is a dynamin inhibitor; inhibits the GTPase activity of dynamin I (Ki = 940 nM; IC50 = 3.1 μM). Targets the dynamin-phospholipid interaction. Inhibits receptor-mediated endocytosis of epidermal growth factor (EGF) in non-neuronal cells; also inhibits synaptic vesicle endocytosis. Displays dynamin I-inhibitory activity similar to OctMAB (Cat. No. 4225).
Technical Data for MitMAB
| M. Wt | 336.39 |
| Formula | C17H38BrN |
| Storage | Desiccate at RT |
| CAS Number | 1119-97-7 |
| PubChem ID | 14250 |
| InChI Key | CXRFDZFCGOPDTD-UHFFFAOYSA-M |
| Smiles | C[N+](C)(C)CCCCCCCCCCCCCC.[Br-] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for MitMAB
References for MitMAB
References are publications that support the biological activity of the product.
Hill et al (2004) Long chain amines and long chain ammonium salts as novel inhibitors of dynamin GTPase activity. Bioorg.Med.Chem.Lett. 14 3275 PMID: 15149689
Quan et al (2007) Myristyl trimethyl ammonium bromide and octadecyl trimethyl ammonium bromide are surface-active small molecule dynamin inhibitors that block endocytosis mediated by dynamin I or dynamin II. Mol.Pharmacol. 72 1425 PMID: 17702890
de Beco et al (2009) Endocytosis is required for E-cadherin redistribution at mature adherens junctions. Proc.Natl.Acad.Sci. 106 7010
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Keywords: MitMAB, MitMAB supplier, dynamin, I, II, inhibitors, inhibits, gtpase, endocytosis, MitMAB, Mitosis, Dynamin, 4224, Tocris Bioscience
Citations for MitMAB
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Currently there are no citations for MitMAB.
Reviews for MitMAB
Average Rating: 5 (Based on 1 Review.)
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Apoptosis was induced by MitMAB in PC3 cells.
By
Anonymous on 02/11/2019
Species: Human
Apoptosis was induced by MitMAB in PC3 cells. The figure shows the results from DAPI staining obtained via EVOSTM Floid Florescence Microscope X80 magnification.
