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Submit ReviewMJ 15
Description: Potent and selective CB1 antagonist
Chemical Name: 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(3-pyridinylmethyl)-1H-pyrazole-3-carboxamide
Purity: ≥99% (HPLC)
Biological Activity for MJ 15
MJ 15 is a potent and selective CB1 receptor antagonist (Ki = 27.2 pM, IC50 = 118.9 pM for rat CB1 receptors). Exhibits potency in obesity and hyperlipidemia models; inhibits food intake and increases in body weight in diet-induced obese rats and mice.
Licensing Information
Sold under licence.
Technical Data for MJ 15
| M. Wt | 471.77 |
| Formula | C23H17Cl3N4O |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 944154-76-1 |
| PubChem ID | 59377482 |
| InChI Key | PJEIKJFNEFJFLA-UHFFFAOYSA-N |
| Smiles | ClC1=CC(Cl)=CC=C1N2C(C3=CC=C(Cl)C=C3)=C(C)C(C(NCC4=CC=CN=C4)=O)=N2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for MJ 15
References for MJ 15
References are publications that support the biological activity of the product.
Chen et al (2010) Novel, selective antagonist of the cannabinoid CB1 receptor, MJ15, with prominent anti-obesity effect in rodent models. Eur.J.Pharmacol. 637 178 PMID: 20380831
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Keywords: MJ 15, MJ 15 supplier, MJ15, CB1, receptors, antagonist, cannabinoid, 1, antagonists, obesity, dyslipidemia, dyslipidaemia, Receptors, 4063, Tocris Bioscience
2 Citations for MJ 15
Citations are publications that use Tocris products. Selected citations for MJ 15 include:
Tan and Cao (2018) Cannabinoid WIN-55,212-2 mesylate inhibits tumor necrosis factor-α-induced expression of nitric oxide synthase in dorsal root ganglion neurons. Int J Mol Med 42 919 PMID: 29786105
Kong et al (2016) Cannabinoid WIN-55,212-2 mesylate inhibits ADAMTS-4 activity in human osteoarthritic articular chondrocytes by inhibiting expression of syndecan-1. J Virol 13 4569 PMID: 27082728
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