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Submit ReviewML 161
Description: Inhibits PAR1-mediated platelet activation
Chemical Name: 2-Bromo-N-[3-[(1-oxobutyl)amino]phenyl]benzamide
Purity: ≥98% (HPLC)
Biological Activity for ML 161
ML 161 is an inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50 = 0.26 μM for the inhibition of platelet P-selectin expression on human platelets). Thought to act allosterically. Also inhibits thrombin-induced platelet activation.
Technical Data for ML 161
| M. Wt | 361.23 |
| Formula | C17H17BrN2O2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 423735-93-7 |
| PubChem ID | 1048267 |
| InChI Key | DFOVLSMXPWPCFH-UHFFFAOYSA-N |
| Smiles | O=C(NC2=CC(NC(CCC)=O)=CC=C2)C1=CC=CC=C1Br |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for ML 161
References for ML 161
References are publications that support the biological activity of the product.
Dockendorff et al (2012) Discovery of 1,3-diaminobenzenes as selective inhibitors of platelet activation at the PAR1 receptor. ACS Med.Chem.Lett. 3 232 PMID: 22408714
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Keywords: ML 161, ML 161 supplier, ML161, inhibitors, inhibits, protease-activated, proteinase-activated, receptors, par1, Protease-Activated, Receptors, 4570, Tocris Bioscience
Citations for ML 161
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Currently there are no citations for ML 161.
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