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Description: Selective GPR55 agonist; also promotes NSC proliferation and differentiation
Alternative Names: CID 20440433
Chemical Name: 3-[[4-(2,3-Dimethylphenyl)-1-piperazinyl]carbonyl]-N,N-dimethyl-4-(1-pyrrolidinyl)benzenesulfonamide
Purity: ≥98% (HPLC)
Biological Activity for ML 184
ML 184 is a selective GPR55 agonist (EC50 = 250 nM). Exhibits >100-fold selectivity for GPR55 over GPR35, CB1 and CB2. Increases proliferation of neural stem cells and promotes neuronal differentiation in vitro.
Compound Libraries for ML 184
ML 184 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.
Technical Data for ML 184
| M. Wt | 470.63 |
| Formula | C25H34N4O3S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 794572-10-4 |
| PubChem ID | 2440433 |
| InChI Key | VRSJAHQGJHDACS-UHFFFAOYSA-N |
| Smiles | CN(S(=O)(C1=CC(C(N2CCN(C3=C(C(C)=CC=C3)C)CC2)=O)=C(N4CCCC4)C=C1)=O)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ML 184
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.41 | 20 |
Preparing Stock Solutions for ML 184
The following data is based on the product molecular weight 470.63. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 10.62 mL | 53.12 mL | 106.24 mL |
| 1 mM | 2.12 mL | 10.62 mL | 21.25 mL |
| 2 mM | 1.06 mL | 5.31 mL | 10.62 mL |
| 10 mM | 0.21 mL | 1.06 mL | 2.12 mL |
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Product Datasheets for ML 184
References for ML 184
References are publications that support the biological activity of the product.
Hill et al (2018) Activation of GPR55 increases neural stem cell proliferation and promotes early adult hippocampal neurogenesis. Br.J.Pharmacol. 175 3407 PMID: 29888782
Kotsikorou et al (2011) Identification of the GPR55 agonist binding site using a novel set of high-potency GPR55 selective ligands. Biochemistry 50 5633 PMID: 21534610
If you know of a relevant reference for ML 184, please let us know.
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Keywords: ML 184, ML 184 supplier, ML184, gpr55, agonists, agonism, selective, neural, stem, cell, proliferation, differentiation, NSC, CID, 20440433, GPR55, Neural, Stem, Cells, 6668, Tocris Bioscience
Citations for ML 184
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Literature in this Area
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Cannabinoid Receptor Ligands Scientific Review
Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.