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Submit ReviewML 190
Description: Selective κ opioid receptor antagonist
Chemical Name: N-[3-[4-(4-Methoxyphenyl)-1-piperazinyl]propyl]-1-methyl-6-oxopyrido[2,3-e]pyrrolo[1,2-a]pyrazine-5(6H)-acetamide
Purity: ≥98% (HPLC)
Biological Activity for ML 190
ML 190 is a selective κ opioid receptor (KOP) antagonist (IC50 = 120 nM in a β-arrestin assay); displays >267-fold selectivity over μ and δ opioid receptors.
Technical Data for ML 190
| M. Wt | 488.58 |
| Formula | C27H32N6O3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1355244-02-8 |
| PubChem ID | 44665680 |
| InChI Key | PMTIWRPLQBVEMR-UHFFFAOYSA-N |
| Smiles | O=C(CN4C(C3=CC=CN3C5=C4N=CC=C5C)=O)NCCCN(CC2)CCN2C1=CC=C(OC)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ML 190
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.77 | 20 |
Preparing Stock Solutions for ML 190
The following data is based on the product molecular weight 488.58. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 10.23 mL | 51.17 mL | 102.34 mL |
| 1 mM | 2.05 mL | 10.23 mL | 20.47 mL |
| 2 mM | 1.02 mL | 5.12 mL | 10.23 mL |
| 10 mM | 0.2 mL | 1.02 mL | 2.05 mL |
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Product Datasheets for ML 190
References for ML 190
References are publications that support the biological activity of the product.
Frankowski et al (2012) Discovery of small molecule kappa opioid receptor agonist and antagonist chemotypes through a HTS and hit refinement strategy. ACS Chem.Neurosci. 3 221 PMID: 22737280
Hedrick et al (2011) Antagonist for the kappa opioid receptor. Probe Reports from the NIH Molecular Libraries Pro PMID: 22091479
If you know of a relevant reference for ML 190, please let us know.
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Keywords: ML 190, ML 190 supplier, ML190, selective, κ-opioid, kappa-opioid, antagonists, KOP, Receptors, OP, Kappa, Opioid, 4866, Tocris Bioscience
Citations for ML 190
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