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Submit ReviewML 193
Description: Potent, selective GPR55 antagonist
Alternative Names: CID 1261822
Chemical Name: N-[4-[[(3,4-Dimethyl-5-isoxazolyl)amino]sulfonyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamide
Purity: ≥98% (HPLC)
Biological Activity for ML 193
ML 193 is a selective GPR55 antagonist (IC50 = 221 nM). Exhibits >27-, >145- and >145-fold selectivity for GPR55 over CB1, GPR35 and CB2, respectively. Inhibits ERK signaling in vitro.
Technical Data for ML 193
| M. Wt | 527.59 |
| Formula | C28H25N5O4S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 713121-80-3 |
| PubChem ID | 1261822 |
| InChI Key | HTSLEZOTMYUPLU-UHFFFAOYSA-N |
| Smiles | CC2=CC(C)=CC1=C(C(NC4=CC=C(S(=O)(NC5=C(C)C(C)=NO5)=O)C=C4)=O)C=C(C3=CC=CC=N3)N=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ML 193
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 52.76 | 100 |
Preparing Stock Solutions for ML 193
The following data is based on the product molecular weight 527.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.9 mL | 9.48 mL | 18.95 mL |
| 5 mM | 0.38 mL | 1.9 mL | 3.79 mL |
| 10 mM | 0.19 mL | 0.95 mL | 1.9 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.38 mL |
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Product Datasheets for ML 193
References for ML 193
References are publications that support the biological activity of the product.
Heynen-Genel et al (2010) Screening for selective ligands for GPR55 - antagonists. Probe Reports from the NIH Molecular Libraries Program PMID: 22091481
Kotsikorou et al (2013) Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligands. Biochemistry 52 9456 PMID: 24274581
If you know of a relevant reference for ML 193, please let us know.
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Keywords: ML 193, ML 193 supplier, ML193, CID1261822, GPR55, agonists, potent, selective, agonism, cannabinoids, CID, 1261822, 4860, Tocris Bioscience
3 Citations for ML 193
Citations are publications that use Tocris products. Selected citations for ML 193 include:
Saliba et al (2018) Anti-neuroinflammatory effects of GPR55 antagonists in LPS-activated primary microglial cells. J Neuroinflammation 15 322 PMID: 30453998
Drzazga (2017) Lysophosphatidylcholine elicits intracellular calcium signaling in GPR55-dependent manner. Biochem Biophys Res Commun 489 243 PMID: 28552523
Alharris et al (2019) Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells. Oncotarget 10 45 PMID: 30713602
Do you know of a great paper that uses ML 193 from Tocris? Please let us know.
Reviews for ML 193
Average Rating: 5 (Based on 1 Review.)
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ML-193 effect on microglia immunal function.
By
Anonymous on 09/21/2019
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Hippocampus
ML-193 was used to study the effect of receptor GPR-55 on release of prostaglandin E2 from hippocampal microglia. ML-193 triggered highly significant lowering of the prostaglandin release compared to control; however, difference between the effects of four tested doses was non-significant (see figure).
Soluble in DMSO, perfectly mixes with artificial cerebro-spinal fluid.
Literature in this Area
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Cannabinoid Receptor Ligands Scientific Review
Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.