ML 218 hydrochloride

Cat. No. 4507 6 Citations Submit a Review Datasheet / COA / SDS

Pricing	Availability		Qty

Description: Ca_V3.x blocker

Chemical Name: 3,5-Dichloro-N-[[(1α,5α,6-exo,6α)-3-(3,3-dimethylbutyl)-3-azabicyclo[3.1.0]hex-6-yl]methyl]-benzamide hydrochloride

Purity: ≥99% (HPLC)

Datasheet

Citations (6)

Reviews

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for ML 218 hydrochloride

ML 218 hydrochloride is a selective inhibitor of T-type calcium channels (IC₅₀ values are 270 and 310 nM for Ca_v3.3 and Ca_v3.2 respectively in a patch EP assay). Decreases burst activity in STN neurons; reduces cataleptic behaviour in an in vivo rat model of Parkinson's disease. Displays no significant inhibition of L- or N-type calcium channels, K_ir6 (K_ATP) or K_V11.1 (hERG) potassium channels. ML 218 hydrochloride inhibits oral cancer cell proliferation. Orally active.

Compound Libraries for ML 218 hydrochloride

ML 218 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ML 218 hydrochloride

M. Wt	405.79
Formula	C₁₉H₂₆Cl₂N₂O.HCl
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	2319922-08-0
PubChem ID	2723792
InChI Key	JIQFFACVQXXHMY-YDALLXLXSA-N
Smiles	CC(C)(C)CCN1C[C@@]2([H])[C@@]([C@@H]2CNC(C3=CC(Cl)=CC(Cl)=C3)=O)([H])C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ML 218 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	36.93	100
	ethanol	36.93	100

Preparing Stock Solutions for ML 218 hydrochloride

The following data is based on the product molecular weight 405.79. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.46 mL	12.32 mL	24.64 mL
5 mM	0.49 mL	2.46 mL	4.93 mL
10 mM	0.25 mL	1.23 mL	2.46 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

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Product Datasheets for ML 218 hydrochloride

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for ML 218 hydrochloride

References are publications that support the biological activity of the product.

Xiang et al (2011) The discovery and characterization of ML218: A novel, centrally active T-type calcium channel inhibitor with robust effects in STN neurons and in a rodent model of Parkinson's disease. ACS Chem.Neurosci. 2 730 PMID: 22368764

Galvan et al (2016) Lack of antiparkinsonian effects of systemic injections of the specific T-type calcium channel blocker ML218 in MPTP-treated monkeys. ACS Chem.Neurosci 7 1543 PMID: 27596273

Chakraborty et al (2021) ML218 HCl is more efficient than capsaicin in inhibiting bacterial antigen-induced Cal 27 oral cancer cell proliferation. Int.J.Mol.Sci. 22 12559 PMID: 34830441

If you know of a relevant reference for ML 218 hydrochloride, please let us know.

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