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ML 233

Cat. No. 5966 Submit a Review Datasheet / COA / SDS
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Description: Non-peptide apelin agonist
Chemical Name: (E)-4-Methyl-5-(((phenylsulfonyl)oxy)imino)-[1,1'-bi(cyclohexane)]-3,6-dien-2-one
Purity: ≥98% (HPLC)
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for ML 233

ML 233 is a non-peptide apelin receptor agonist (EC50 = 3.7 μM); exhibits >21-fold selectivity over the closely related angiotensin 1 receptor (EC50 = >79 μM).

Technical Data for ML 233

M. Wt 359.44
Formula C19H21NO4S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2080311-92-6
PubChem ID 60138111
InChI Key RSMZOLWJZGIWOV-CZIZESTLSA-N
Smiles CC(/C(C=C1C2CCCCC2)=N/OS(C3=CC=CC=C3)(=O)=O)=CC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ML 233

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 17.97 50

Preparing Stock Solutions for ML 233

The following data is based on the product molecular weight 359.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.56 mL 27.82 mL 55.64 mL
2.5 mM 1.11 mL 5.56 mL 11.13 mL
5 mM 0.56 mL 2.78 mL 5.56 mL
25 mM 0.11 mL 0.56 mL 1.11 mL

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References for ML 233

References are publications that support the biological activity of the product.

Yang et al (2015) Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system. Trends Pharmacol Sci. 36 560 PMID: 26143239

Khan et al (2011) Functional agonists of the apelin (APJ) receptor. Probe Reports from the NIH Molecular Libraries Program PMID: 22834038

If you know of a relevant reference for ML 233, please let us know.

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Citations for ML 233

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