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Submit ReviewML 3403
Description: p38 inhibitor
Chemical Name: [5-[4-(4-Fluorophenyl)-2-methylthio-1H-imidazol-4-yl]-N-(1-phenylethyl)-2-pyridinamine
Purity: ≥98% (HPLC)
Biological Activity for ML 3403
ML 3403 is a p38 MAPK inhibitor (IC50 = 0.38 μM). Inhibits the release of IL-1β and TNF-α in a peripheral blood mononuclear cell (PBMC) assay (IC50 values are 0.039 and 0.16 μM respectively).
Compound Libraries for ML 3403
ML 3403 is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.
Technical Data for ML 3403
| M. Wt | 404.5 |
| Formula | C23H21FN4S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 549505-65-9 |
| PubChem ID | 6419739 |
| InChI Key | VXPWQNBKEIVYIS-UHFFFAOYSA-N |
| Smiles | FC(C=C3)=CC=C3C(N=C(SC)N2)=C2C1=CC=NC(NC(C)C4=CC=CC=C4)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for ML 3403
References for ML 3403
References are publications that support the biological activity of the product.
Laufer et al (2003) Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes. J.Med.Chem. 46 3230 PMID: 12852754
Kammerer et al (2007) Pharmacokinetics of ML3403 ({4-[5-(4-fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-(1-phenylethyl)-amine), a 4-pyridinylimidazole-type p38 mitogen-activated protein kinase inhibitor. Drug Metab.Dispos. 35 875 PMID: 17344341
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Keywords: ML 3403, ML 3403 supplier, ML3403, p38, MAPK, mitogen-activated, protein, kinase, inhibitors, inhibits, 4586, Tocris Bioscience
Citations for ML 3403
Citations are publications that use Tocris products.
Currently there are no citations for ML 3403.
Reviews for ML 3403
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.
Pathways for ML 3403
