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Submit ReviewMLS 1547
Description: G protein-biased D2 partial agonist
Chemical Name: 5-Chloro-7-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-8-quinolinol
Purity: ≥98% (HPLC)
Biological Activity for MLS 1547
MLS 1547 is a G protein-biased D2 receptor partial agonist (Ki = 1.2 μM). Stimulates D2 receptor G protein-mediated signaling and acts as an antagonist of dopamine-mediated β-arrestin recruitment at D2 receptors.
Compound Libraries for MLS 1547
MLS 1547 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for MLS 1547
| M. Wt | 354.83 |
| Formula | C19H19ClN4O |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 315698-36-3 |
| PubChem ID | 1093278 |
| InChI Key | OPEJNANYABTIGC-UHFFFAOYSA-N |
| Smiles | OC1=C(C=C(C2=C1N=CC=C2)Cl)CN3CCN(C4=CC=CC=N4)CC3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for MLS 1547
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.48 | 100 |
Preparing Stock Solutions for MLS 1547
The following data is based on the product molecular weight 354.83. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.82 mL | 14.09 mL | 28.18 mL |
| 5 mM | 0.56 mL | 2.82 mL | 5.64 mL |
| 10 mM | 0.28 mL | 1.41 mL | 2.82 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
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Product Datasheets for MLS 1547
References for MLS 1547
References are publications that support the biological activity of the product.
Free et al (2014) Discovery and characterization of a G protein-biased agonist that inhibits β-arrestin recruitment to the D2 DA receptor. Mol.Pharmacol. 86 96 PMID: 24755247
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Keywords: MLS 1547, MLS 1547 supplier, MLS1547, dopamine, D2, DA, partial, agonists, agonism, G, protein, biased, signaling, Receptors, 6171, Tocris Bioscience
2 Citations for MLS 1547
Citations are publications that use Tocris products. Selected citations for MLS 1547 include:
Stefan et al (2021) New phosphosite-specific antibodies to unravel the role of GRK phosphorylation in dopamine D2 receptor regulation and signaling. Sci Rep 11 8288 PMID: 33859231
Ting et al (2021) Exploiting D2 receptor β-arrestin2-biased signalling to suppress tumour growth of pituitary adenomas. Br J Pharmacol 178 3570-3586 PMID: 33904172
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.