Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewMM 54
Description: Potent apelin antagonist
Purity: ≥95% (HPLC)
Biological Activity for MM 54
MM 54 is a potent apelin receptor antagonist (Ki = 82 nM; IC50 = 93 nM). Antagonizes the inhibitory affect of [Pyr1]-Apelin-13 on forskolin-induced cAMP accumulation in CHO-K1-APJ cells. Recuces tumor expansion and lengthens survival time in a mouse xenograft model of glioblastoma.
Technical Data for MM 54
| M. Wt | 1737.15 |
| Formula | C70H121N29O15S4 |
| Sequence |
CRPRLCKHCRPRLC (Modifications: Disulfide bridges: 1-6, 9-14) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 1313027-43-8 |
| PubChem ID | 122705991 |
| InChI Key | BMJYNYGARUVBJU-CSRTWURCSA-N |
| Smiles | [H]N[C@H]1CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC1=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC1=O)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for MM 54
| Solubility | Soluble to 2 mg/ml in water |
Product Datasheets for MM 54
References for MM 54
References are publications that support the biological activity of the product.
Macaluso et al (2011) Discovery of a competitive apelin receptor (APJ) antagonist. ChemMedChem 6 1017 PMID: 21560248
Harford-Wright et al (2017) Pharmacological targeting of apelin impairs glioblastoma growth. Brain 140 2939 PMID: 29053791
If you know of a relevant reference for MM 54, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: MM 54, MM 54 supplier, MM54, potent, apelin, receptors, antagonists, antagonism, Apelin, Receptors, 5992, Tocris Bioscience
Citations for MM 54
Citations are publications that use Tocris products.
Currently there are no citations for MM 54. Do you know of a great paper that uses MM 54 from Tocris? Please let us know.
Reviews for MM 54
There are currently no reviews for this product. Be the first to review MM 54 and earn rewards!
Have you used MM 54?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image