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MMG 11

Cat. No. 6858 Submit a Review Datasheet / COA / SDS
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Description: TLR2 antagonist
Chemical Name: Ethyl 5-(2-oxo-2-(2,3,4-trihydroxyphenyl)ethyl)furan-2-carboxylate
Purity: ≥97% (HPLC)
Datasheet
Citations
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Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for MMG 11

MMG 11 is a TLR2 antagonist (IC50 values are in the range 1.7 - 5.7 μM). Exhibits selectivity for TLR2 over TLR4, TLR5, TLR7/8 and TLR9. Reduces TLR2-mediated cytokine secretion from PBMCs. MMG 11 preferentially inhibits TLR2/1- over TLR2/6-mediated NK-κB activation (IC50 values are 0.87 and 7.4 μM, respectively).

Technical Data for MMG 11

M. Wt 306.27
Formula C15H14O7
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 313254-94-3
PubChem ID 854609
InChI Key IIDUJWIVMGALOG-UHFFFAOYSA-N
Smiles CCOC(=O)C1=CC=C(CC(=O)C2=C(O)C(O)=C(O)C=C2)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MMG 11

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.63 100
ethanol 15.31 50

Preparing Stock Solutions for MMG 11

The following data is based on the product molecular weight 306.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.27 mL 16.33 mL 32.65 mL
5 mM 0.65 mL 3.27 mL 6.53 mL
10 mM 0.33 mL 1.63 mL 3.27 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

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References for MMG 11

References are publications that support the biological activity of the product.

Grabowski et al (2019) Identification of a pyrogallol derivative as a potent and selective human TLR2 antagonist by structure-based virtual screening. Biochem.Pharmacol. 154 148 PMID: 29684378

Grabowski et al (2020) The novel small-molecule antagonist MMG-11 preferentially inhibits TLR2/1 signaling. Biochem.Pharmacol. 171 113687 PMID: 31678495

If you know of a relevant reference for MMG 11, please let us know.

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Citations for MMG 11

Citations are publications that use Tocris products.

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Pathways for MMG 11

Toll-like Receptor Signaling Pathway

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.