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Description: Caged NMDA
Alternative Names: 4-Methoxy-7-nitroindolinyl-caged N-methyl-D-aspartic acid
Chemical Name: (R)-α-Methylamino-2,3-dihydro-4-methoxy-7-nitro-γ-oxo-1H-indole-1-butanoic acid
Purity: ≥99% (HPLC)
Biological Activity for MNI-caged-NMDA
MNI-caged-NMDA is a NMDA (Cat.No. 0114) caged with the photosensitive 4-methoxy-7-nitroindolinyl group. Stoichiometrically releases chirally pure NMDA. Suitable for uncaging with 300-380 nm excitation. Improved localization can be achieved by uncaging at 405 nm (with mM concentration of caged compound in the bath solution). Exhibits rapid uncaging rate relative to ionotropic glutamate receptor activation.
Licensing Information
Sold under license from the UK Medical Research Council
Technical Data for MNI-caged-NMDA
| M. Wt | 323.3 |
| Formula | C14H17N3O6 |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 1227675-52-6 |
| PubChem ID | 57369294 |
| InChI Key | MUCRWOILMOHLGD-SECBINFHSA-N |
| Smiles | O=C(C[C@H](C(O)=O)NC)N2C1=C([N+]([O-])=O)C=CC(OC)=C1CC2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for MNI-caged-NMDA
References for MNI-caged-NMDA
References are publications that support the biological activity of the product.
Palma-Cerda et al (2012) New caged neurotransmitter analogs selective for glutamate receptor sub-types based on methoxynitroindoline and nitrophenylethoxycarbonyl caging groups. Neuropharmacology. 63 624 PMID: 22609535
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Keywords: MNI-caged-NMDA, MNI-caged-NMDA supplier, Caged, NMDA, Compounds, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, MNI-NMDA, 4-Methoxy-7-nitroindolinyl-caged, N-methyl-D-aspartic, acid, 2224, Tocris Bioscience
1 Citation for MNI-caged-NMDA
Citations are publications that use Tocris products. Selected citations for MNI-caged-NMDA include:
Zhang et al (2016) Stereotyped initiation of retinal waves by bipolar cells via presynaptic NMDA autoreceptors. Nat.Commun. 7 12650 PMID: 27586999
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