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Submit ReviewMontelukast sodium
Description: CysLT1 and GPR17 antagonist
Chemical Name: 1-[[[(1R)-1-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid sodium salt
Purity: ≥99% (HPLC)
Biological Activity for Montelukast sodium
Montelukast sodium is a cysteinyl leukotriene receptor 1 (CysLT1) and GPR17 antagonist. Blocks pentylenetetrazole-induced seizures, blood brain barrier (BBB) disruption and leukocyte migration in mice. Reduces neuroinflammation, improves BBB integrity, enhances learning and memory, and restores hippocampal neurogenesis and cognitive function in aged rats. Orally active and brain penetrant.
Compound Libraries for Montelukast sodium
Montelukast sodium is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for Montelukast sodium
| M. Wt | 608.17 |
| Formula | C35H35ClNNaO3S |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 151767-02-1 |
| PubChem ID | 23663996 |
| InChI Key | LBFBRXGCXUHRJY-HKHDRNBDSA-M |
| Smiles | CC(O)(C1=C(C=CC=C1)CC[C@H](C2=CC(/C=C/C3=NC4=CC(Cl)=CC=C4C=C3)=CC=C2)SCC5(CC5)CC(O[Na])=O)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Montelukast sodium
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 30.41 | 50 | |
| DMSO | 60.82 | 100 |
Preparing Stock Solutions for Montelukast sodium
The following data is based on the product molecular weight 608.17. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.64 mL | 8.22 mL | 16.44 mL |
| 5 mM | 0.33 mL | 1.64 mL | 3.29 mL |
| 10 mM | 0.16 mL | 0.82 mL | 1.64 mL |
| 50 mM | 0.03 mL | 0.16 mL | 0.33 mL |
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Product Datasheets for Montelukast sodium
References for Montelukast sodium
References are publications that support the biological activity of the product.
Lenz et al (2014) Cysteinyl leukotriene receptor (CysLT) antagonists decrease pentylenetetrazol-induced seizures and blood-brain barrier dysfunction. Neuroscience 277 859 PMID: 25090924
Marschallinger et al (2015) Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug. Nat.Commun. 6 8466 PMID: 26506265
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Keywords: Montelukast sodium, Montelukast sodium supplier, Leukotriene, D4, antagonists, antagonism, cysteinyl, receptors, CysLT1, seizures, blood, brain, barrier, disruption, epilepsy, GPR17, and, Related, Receptors, 5904, Tocris Bioscience
1 Citation for Montelukast sodium
Citations are publications that use Tocris products. Selected citations for Montelukast sodium include:
Wright et al (2019) Pranlukast is a novel small molecule activator of the two-pore domain potassium channel TREK2. Biochem Biophys Res Commun 520 35 PMID: 31564414
Do you know of a great paper that uses Montelukast sodium from Tocris? Please let us know.
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