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Submit ReviewMotilin (human, porcine)
Description: Endogenous peptide regulator of gastrointestinal motility
Purity: ≥95% (HPLC)
Biological Activity for Motilin (human, porcine)
Motilin (human, porcine) is an endogenous motilin receptor ligand (Ki = 2.3 nM) that regulates gastrointestinal motor function. Stimulates contraction of gut smooth muscle (EC50 = 1 nM) and increases pepsin release.
Technical Data for Motilin (human, porcine)
| M. Wt | 2699.07 |
| Formula | C120H188N34O35S |
| Sequence | FVPIFTYGELQRMQEKERNKGQ |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 52906-92-0 |
| PubChem ID | 16136567 |
| InChI Key | LVRVABPNVHYXRT-BQWXUCBYSA-N |
| Smiles | [H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Motilin (human, porcine)
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for Motilin (human, porcine)
References for Motilin (human, porcine)
References are publications that support the biological activity of the product.
Itoh (1997) Motilin and clinical application. Peptides 18 593 PMID: 9210180
Coulie et al (2001) Identification of peptide ligand-binding domains within the human motilin receptor using photoaffinity labeling. J.Biol.Chem. 276 35518 PMID: 11461914
Huang et al (2005) Signaling pathways mediating gastrointestinal smooth muscle contraction and MLC20 phosphorylation by motilin receptors. Am.J.Physiol.Gastrointest.Liver Physiol. 288 G23 PMID: 15591586
If you know of a relevant reference for Motilin (human, porcine), please let us know.
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Keywords: Motilin (human, porcine), Motilin (human, porcine) supplier, Endogenous, peptide, regulator, gastrointestinal, motility, Motilin, Receptors, 2264, Tocris Bioscience
1 Citation for Motilin (human, porcine)
Citations are publications that use Tocris products. Selected citations for Motilin (human, porcine) include:
Broad and Sanger (2013) The antibiotic azithro. is a motilin receptor agonist in human stomach: comparison with erythro. Br J Pharmacol 168 1859 PMID: 23190027
Do you know of a great paper that uses Motilin (human, porcine) from Tocris? Please let us know.
Reviews for Motilin (human, porcine)
Average Rating: 5 (Based on 1 Review.)
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GI tissue bath.
By
John Broad on 01/05/2018
Assay Type: In Vitro
Species: Human
Caused contraction of GI smooth muscle 10-300 nM
Soluble in H2O
