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Submit ReviewMPC 6827 hydrochloride
Description: Inhibitor of microtubule polymerization; antimitotic and antitumor
Chemical Name: N-(4-Methoxyphenyl)-N,2-dimethyl-4-quinazolinamine hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for MPC 6827 hydrochloride
MPC 6827 hydrochloride is a potent inhibitor of microtubule formation (IC50 = 1.5 - 3.4 nM); inhibits polymerization of tubulin in vitro and disrupts microtubule formation in several cancer cell lines. Inhibits tumor growth in vitro and in vivo; exhibits pro-apoptotic characteristics. Brain penetrant.
Technical Data for MPC 6827 hydrochloride
| M. Wt | 315.8 |
| Formula | C17H17N3O.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 917369-31-4 |
| PubChem ID | 11638255 |
| InChI Key | VYUWDIKZJLOZJL-UHFFFAOYSA-N |
| Smiles | CC2=NC1=CC=CC=C1C(N(C)C3=CC=C(OC)C=C3)=N2.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for MPC 6827 hydrochloride
References for MPC 6827 hydrochloride
References are publications that support the biological activity of the product.
Mahal et al (2014) Effects of the tumor-vasculature-disrupting agent verubulin and two heteroaryl analogues on cancer cells, endothelial cells, and blood vessels. ChemMedChem. 9 847 PMID: 24678059
Kasibhatla et al (2007) MPC-6827: a small-molecule inhibitor of microtubule formation that is not a substrate for multidrug resistance pumps. Cancer Res. 67 5865 PMID: 17575155
Sirisoma et al (2009) Discovery of N-(4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine, a potent apoptosis inducer and efficacious anticancer agent with high blood brain barrier penetration. J.Med.Chem. 52 2341 PMID: 19296653
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2 Citations for MPC 6827 hydrochloride
Citations are publications that use Tocris products. Selected citations for MPC 6827 hydrochloride include:
Christopher T et al (2022) Initial Evaluations of the Microtubule-Based PET Radiotracer, [11C]MPC-6827 in a Rodent Model of Cocaine Abuse. Front Med (Lausanne) 9 817274 PMID: 35295607
Suzanne et al (2022) Preliminary mechanistic insights of a brain-penetrant microtubule imaging PET ligand in a tau-knockout mouse model. EJNMMI Res 12 41 PMID: 35881263
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Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
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