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Submit ReviewMRS 2211
Description: Competitive P2Y13 antagonist
Chemical Name: 2-[(2-Chloro-5-nitrophenyl)azo]-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]-4-pyridinecarboxaldehyde disodium salt
Purity: ≥96% (HPLC)
Biological Activity for MRS 2211
MRS 2211 is a competitive P2Y13 receptor antagonist (pIC50 = 5.97) that displays > 20-fold selectivity over P2Y1 and P2Y12 receptors.
Technical Data for MRS 2211
| M. Wt | 474.66 |
| Formula | C14H10N4O8Na2PCl |
| Storage | Desiccate at -20°C |
| Purity | ≥96% (HPLC) |
| PubChem ID | 57369297 |
| InChI Key | VLNWYJFCKRYEJA-QIKYXUGXSA-L |
| Smiles | [Na+].[Na+].CC1=C(O)C(C=O)=C(COP([O-])([O-])=O)C(\N=N\C2=C(Cl)C=CC(=C2)[N+]([O-])=O)=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for MRS 2211
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 33.23 | 70 |
Preparing Stock Solutions for MRS 2211
The following data is based on the product molecular weight 474.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.7 mM | 3.01 mL | 15.05 mL | 30.1 mL |
| 3.5 mM | 0.6 mL | 3.01 mL | 6.02 mL |
| 7 mM | 0.3 mL | 1.5 mL | 3.01 mL |
| 35 mM | 0.06 mL | 0.3 mL | 0.6 mL |
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Product Datasheets for MRS 2211
References for MRS 2211
References are publications that support the biological activity of the product.
Kim et al (2005) Synthesis of pyridoxal phosphate derivatives with antagonist activity at the P2Y13 receptor. Biochem.Pharmacol. 70 266 PMID: 15913566
Kugelgen (2006) Pharmacological profiles of cloned mammalian P2Y-receptor subtypes. Pharmacol.Ther. 110 415 PMID: 16257449
If you know of a relevant reference for MRS 2211, please let us know.
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Keywords: MRS 2211, MRS 2211 supplier, Competitive, P2Y13, antagonists, Receptors, Purinergic, purinoceptors, MRS2211, 219554-11-7, antagonises, inhibitors, inhibits, P2Y, 2402, Tocris Bioscience
10 Citations for MRS 2211
Citations are publications that use Tocris products. Selected citations for MRS 2211 include:
Madry et al (2018) Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K+ Channel THIK-1. Neuron 97 299 PMID: 29290552
Kawano et al (2015) Autocrine Regulation of UVA-Induced IL-6 Production via Release of ATP and Activation of P2Y Receptors. PLoS One 10 e0127919 PMID: 26030257
Voss et al (2014) The enteric nervous system of P2Y13 receptor null mice is resistant against high-fat-diet- and palmitic-acid-induced neuronal loss. Purinergic Signal 10 455 PMID: 24510452
Gao et al (2013) The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells. Mol Cancer 9 31 PMID: 22825617
Ohtomo et al (2011) Increase of intracellular Ca2+ by purinergic receptors in cultured rat lacrimal gland myoepithelial cells. Invest Ophthalmol Vis Sci 52 9503 PMID: 22039237
Pinheiro et al (2013) Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation. Cell Commun Signal 11 70 PMID: 24047499
Balduini et al (2012) Constitutively released adenosine diphosphate regulates proplatelet formation by human megakaryocytes. Haematologica 97 1657 PMID: 22689668
Puerto et al (2012) Adenylate cyclase 5 coordinates the action of ADP, P2Y1, P2Y13 and ATP-gated P2X7 receptors on axonal elongation. J Cell Sci 125 176 PMID: 22250198
Wang et al (2014) Nucleolin down-regulation is involved in ADP-induced cell cycle arrest in S phase and cell apoptosis in vascular endothelial cells. PLoS One 9 e110101 PMID: 25290311
Giachini et al (2014) Anti-platelet therapy with clopid. prevents endothelial dysfunction and vascular remodeling in aortas from hypertensive rats. PLoS One 9 e91890 PMID: 24638017
Do you know of a great paper that uses MRS 2211 from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
P2X and P2Y Receptors Scientific Review
Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.