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Submit ReviewMRS 2693 trisodium salt
Description: Selective P2Y6 agonist
Alternative Names: 5-Iodo-UDP trisodium salt
Chemical Name: 5-Iodouridine-5'-O-diphosphate trisodium salt
Purity: ≥95% (HPLC)
Biological Activity for MRS 2693 trisodium salt
MRS 2693 trisodium salt is a selective P2Y6 agonist (EC50 = 0.015 μM at the hP2Y6 receptor). Displays no activity at other P2Y subtypes. Exerts a cytoprotective effect in an in vivo mouse model of hindlimb skeletal muscle ischemia/reperfusion injury.
Technical Data for MRS 2693 trisodium salt
| M. Wt | 596 |
| Formula | C9H10IN2Na3O12P2 |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 1448858-83-0 |
| PubChem ID | 90488768 |
| InChI Key | QWGVSYFNEAILDQ-FCIXCQMASA-K |
| Smiles | [Na+].[Na+].[Na+].O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])(=O)OP([O-])([O-])=O)N1C=C(I)C(=O)NC1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for MRS 2693 trisodium salt
| Solubility | Soluble in water (supplied pre-dissolved at a concentration of 10mM) |
Product Datasheets for MRS 2693 trisodium salt
References for MRS 2693 trisodium salt
References are publications that support the biological activity of the product.
Besada et al (2006) Structure-activity relationships of uridine 5'-diphosphate analogues at the human P2Y6 receptor. J.Med.Chem. 49 5532 PMID: 16942026
Mamedova et al (2008) Attenuation of apoptosis in vitro and ischemia/reperfusion injury in vivo in mouse skeletal muscle by P2Y6 receptor activation. Pharmacol.Res. 58 232 PMID: 18805489
Jacobson et al (2009) Development of selective agonists and antagonists of P2Y receptors. Purinerg.Sig. 5 75
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Keywords: MRS 2693 trisodium salt, MRS 2693 trisodium salt supplier, Selective, P2Y6, purinergic, receptors, agonists, MRS2693, trisodium, salt, 5-Iodo-UDP, Purinergic, P2Y, Receptors, 2502, Tocris Bioscience
4 Citations for MRS 2693 trisodium salt
Citations are publications that use Tocris products. Selected citations for MRS 2693 trisodium salt include:
Moreira-Souza et al (2015) Pyrimidinergic Receptor Activation Controls Toxoplasma gondii Infection in Macrophages. PLoS One 10 e0133502 PMID: 26192447
Matsumoto et al (2011) Uridine adenosine tetraphosphate-induced contraction is increased in renal but not pulmonary arteries from DOCA-salt hypertensive rats. Am J Physiol Heart Circ Physiol 301 H409 PMID: 21551273
Yu et al (2013) Extracellular UDP enhances P2X-mediated bladder smooth muscle contractility via P2Y(6) activation of the phospholipase C/inositol trisphosphate pathway. FASEB J 27 1895 PMID: 23362118
Obba et al (2015) The PRKAA1/AMPKα1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML. Neuropharmacology 11 1114 PMID: 26029847
Do you know of a great paper that uses MRS 2693 trisodium salt from Tocris? Please let us know.
Reviews for MRS 2693 trisodium salt
Average Rating: 5 (Based on 1 Review.)
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Good product.
By
Anonymous on 09/09/2021
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: 1321N1
Used MRS 2693 in a fluorescence-based intracellular calcium assay, and the agonist came pre-dissolved in water to a concentration of 10 mM.
Literature in this Area
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P2X and P2Y Receptors Scientific Review
Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.