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Submit ReviewMRS 2768 tetrasodium salt
Description: Selective P2Y2 agonist
Chemical Name: Uridine-5'-tetraphosphate δ-phenyl ester tetrasodium salt
Purity: ≥98% (HPLC)
Biological Activity for MRS 2768 tetrasodium salt
MRS 2768 tetrasodium salt is a selective P2Y2 agonist (EC50 = 1.89 μM). Displays no affinity for human P2Y4 or P2Y6 receptors. In a mouse model of myocardial infarction, pre-treatment with MRS 2768 protects cardiocytes and heart tissue from ischemic damage, and reduces circulating levels of TNF-α.
Technical Data for MRS 2768 tetrasodium salt
| M. Wt | 728.14 |
| Formula | C15H16N2O18P4Na4 |
| Storage | Store at -80°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2567869-47-8 |
| PubChem ID | 90488893 |
| InChI Key | ASYFBNZFGLWLNC-YYXHNCPRSA-J |
| Smiles | [Na+].[Na+].[Na+].[Na+].O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])(=O)OP([O-])(=O)OP([O-])(=O)OP([O-])(=O)OC1=CC=CC=C1)N1C=CC(=O)NC1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for MRS 2768 tetrasodium salt
| Solubility | Soluble in water (supplied pre-dissolved at a concentration of 10mM) |
Product Datasheets for MRS 2768 tetrasodium salt
References for MRS 2768 tetrasodium salt
References are publications that support the biological activity of the product.
Ko et al (2008) Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists. Bioorg.Med.Chem. 16 6319 PMID: 18514530
Hochhauser et al (2013) P2Y2 receptor agonist with enhanced stability protects the heart from ischemic damage in vitro and in vivo. Purinergic Signal. 9 633 PMID: 23828651
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Keywords: MRS 2768 tetrasodium salt, MRS 2768 tetrasodium salt supplier, selective, P2Y2, agonists, purinergic, receptors, MRS2768, 1047980-83-5, Purinergic, P2Y, Receptors, 3884, Tocris Bioscience
5 Citations for MRS 2768 tetrasodium salt
Citations are publications that use Tocris products. Selected citations for MRS 2768 tetrasodium salt include:
Ilatovskaya et al (2013) Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli. Am J Physiol Cell Physiol 305 C1050 PMID: 24048730
Trabanelli et al (2012) Extracellular ATP exerts opposite effects on activated and regulatory CD4+ T cells via purinergic P2 receptor activation. J Immunol 189 1303 PMID: 22753942
Andreas et al (2020) Osmotic and hypoxic induction of osteopontin in retinal pigment epithelial cells: Involvement of purinergic receptor signaling. Mol Vis 26 188-203 PMID: 32214785
Shabir et al (2013) Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium. PLoS Comput Biol 305 F396 PMID: 23720349
Alsaqati et al (2013) Investigation of the functional expression of purine and pyrimidine receptors in porcine isolated pancreatic arteries. Purinergic Signal 10 241 PMID: 24310605
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
P2X and P2Y Receptors Scientific Review
Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.